{"id":"W3144087614","doi":"10.1016/j.jconrel.2021.03.042","title":"Development and characterization of a novel flavopiridol formulation for treatment of acute myeloid leukemia","year":2021,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"NanoMedicines Innovation Network; University of British Columbia; Occupational Cancer Research Centre","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research","keywords":"Pharmacology; Chemistry; Pharmacokinetics; Liposome; Myeloid leukemia; In vivo; Daunorubicin; Bioavailability; Drug; Quercetin; Leukemia; Medicine; Cancer research; Biochemistry; Immunology; Antioxidant; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001397595,0.0001801106,0.0001216914,0.0001333462,0.00008580798,0.0001548639,0.0001339632,0.0001936401,0.0004574393],"category_scores_gemma":[0.0001302625,0.00007200026,0.0001278411,0.00007761733,0.00008936126,0.0001645757,0.00008431833,0.0002443264,0.0001776751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002146795,"about_ca_system_score_gemma":0.0001311545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005419124,"about_ca_topic_score_gemma":0.0006507951,"domain_scores_codex":[0.9999502,0.00000680093,0.000004566447,0.00001013626,0.00002196741,0.000006472088],"domain_scores_gemma":[0.9999557,0.000005328918,0.00001447528,0.000002652934,0.00001352166,0.000008507171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002019478,0.00002142968,0.00005619449,0.00002343864,0.000002232298,0.00002578888,0.000006417836,0.0001159641,0.9975054,0.00003750782,0.00001987001,0.002165559],"study_design_scores_gemma":[0.00002874029,0.0006231786,0.001389161,0.00000689342,0.00001488634,0.0001581237,0.00001020526,0.001783416,0.9916446,0.00002644721,0.004308905,0.000005503524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804975,0.002319118,0.01468449,0.0001703554,0.0000261994,0.0003263027,0.0003127112,0.00005738219,0.001605934],"genre_scores_gemma":[0.9794177,0.001550106,0.01593144,0.00009956849,0.00001596472,0.0001098273,0.0005204175,0.00001740151,0.002337546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005419124,"threshold_uncertainty_score":0.001557648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02438534645585013,"score_gpt":0.3004305490647416,"score_spread":0.2760452026088915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}