{"id":"W3144147536","doi":"10.3389/fonc.2021.615821","title":"Characterization of Cell Free Plasma Methyl-DNA From Xenografted Tumors to Guide the Selection of Diagnostic Markers for Early-Stage Cancers","year":2021,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"DNA methylation; Methylation; Cancer research; Cancer; Biology; Colorectal cancer; Differentially methylated regions; Breast cancer; Stage (stratigraphy); Lung cancer; Bisulfite sequencing; Metastasis; Gene; Oncology; Medicine; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001857405,0.0001195712,0.0002802823,0.00007044485,0.00003534012,0.000007200531,0.0002237076,0.0001656792,0.00001812762],"category_scores_gemma":[0.001117664,0.0001187457,0.00008414353,0.0002083511,0.00007326958,0.000003473694,0.0001066978,0.0000698211,3.813373e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000183823,"about_ca_system_score_gemma":0.0005679312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007591854,"about_ca_topic_score_gemma":0.002353757,"domain_scores_codex":[0.9989535,0.000100349,0.0003739187,0.0002907437,0.00007791261,0.0002035601],"domain_scores_gemma":[0.9989955,0.0002747502,0.0002142518,0.0002868988,0.0001747347,0.00005384753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005463632,0.00008056049,0.02957971,0.00002976085,0.0000842455,0.000003503278,0.0002786945,0.0008372802,0.9533275,0.00001382449,0.0114409,0.003777605],"study_design_scores_gemma":[0.001286602,0.0006704154,0.02948486,0.00002048079,0.00005315397,8.912127e-7,0.0004283591,0.0004461152,0.8747576,0.0000682718,0.09264841,0.0001348482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790021,0.0002156198,0.01816033,0.0002678379,0.0009081459,0.0004590383,0.0007083914,0.000003398249,0.0002750994],"genre_scores_gemma":[0.976444,0.0008824499,0.02082516,0.0004257752,0.0001923865,0.0001866985,0.0005562968,0.0000302202,0.000457008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08120751,"threshold_uncertainty_score":0.4842308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006279405787231115,"score_gpt":0.2424654478405024,"score_spread":0.2361860420532713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}