{"id":"W3144225459","doi":"10.1007/s13311-021-01015-8","title":"Targeting TDP-43 Pathology Alleviates Cognitive and Motor Deficits Caused by Chronic Cerebral Hypoperfusion","year":2021,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Neurological Disease Mechanisms and Treatments","field":"Neuroscience","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec; Université Laval","funders":"Consortium canadien en neurodégénérescence associée au vieillissement; Canada Research Chairs; Alzheimer Society; Fondation Brain Canada; ALS Society of Canada","keywords":"Dementia; Neuroscience; Medicine; Cognitive decline; Vascular dementia; Neurodegeneration; Neurology; Microglia; Pathology; Psychology; Disease; Inflammation; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001652902,0.0009771856,0.0007597448,0.0003208897,0.0002566685,0.0003822682,0.0005024201,0.0005528919,0.00199612],"category_scores_gemma":[0.0001512382,0.0001886913,0.0003188873,0.0002176419,0.0006234674,0.0004568787,0.0003622896,0.001491135,0.0002838777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003818892,"about_ca_system_score_gemma":0.0008497353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001819972,"about_ca_topic_score_gemma":0.002541463,"domain_scores_codex":[0.999905,0.000008307526,0.000007423334,0.00002120377,0.00001674041,0.00004146211],"domain_scores_gemma":[0.9999155,0.000006802497,0.00002756044,0.000009477499,0.00001037267,0.00003034605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004943994,0.001018367,0.0003438872,0.0005096066,0.0001620247,0.0005303585,0.00007216318,0.0006401361,0.9619672,0.0006676601,0.001057873,0.02808668],"study_design_scores_gemma":[0.001446547,0.01466288,0.01781314,0.0001613845,0.0006483582,0.002168927,0.0003136484,0.005425327,0.9428669,0.002490308,0.01192925,0.00007327593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882188,0.003054778,0.005222511,0.0004519621,0.0002379946,0.000096669,0.000289473,0.0004527157,0.001975131],"genre_scores_gemma":[0.9924439,0.002361133,0.001857951,0.000141009,0.00004775057,0.0001179641,0.0002703109,0.00003504725,0.002724826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00199612,"threshold_uncertainty_score":0.006677747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03331781996170371,"score_gpt":0.2660926824139115,"score_spread":0.2327748624522078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}