{"id":"W3144611104","doi":"10.1101/2021.03.26.21254400","title":"IL-18 and Lower Risk for Lung Cancer: Triangulated Evidence from Germline Predictions, Pre-Diagnostic Measurements, and Tumor Expression","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Public Health Ontario; Lunenfeld-Tanenbaum Research Institute","funders":"National Institutes of Health; Cancer Research UK; Centre International de Recherche sur le Cancer; World Health Organization","keywords":"Lung cancer; Mendelian randomization; Cancer; Internal medicine; Carcinogenesis; Immune system; Inflammation; Adenocarcinoma; Quartile; Lung; Oncology; Medicine; CD8; Biology; Immunology; Cancer research; Genotype; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005595176,0.0005712318,0.0004802036,0.001056548,0.0002677107,0.001102367,0.0007759254,0.0008099561,0.002317059],"category_scores_gemma":[0.01733366,0.0003012935,0.0009463937,0.0009291813,0.000641219,0.0004573896,0.0008939647,0.0009868494,0.0003526547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002367587,"about_ca_system_score_gemma":0.0002538602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002979199,"about_ca_topic_score_gemma":0.001616034,"domain_scores_codex":[0.9950251,0.00296111,0.0002414628,0.001132704,0.0004356321,0.0002038853],"domain_scores_gemma":[0.9756652,0.0162752,0.003864932,0.00263636,0.0009283852,0.0006300015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007335768,0.00003327717,0.9920275,0.00003648284,0.001221566,0.0001634809,0.0000697474,0.0004307952,0.0008972033,0.0001580087,0.0001273193,0.004100966],"study_design_scores_gemma":[0.00007974048,0.0004935597,0.985968,0.0000730344,0.001857214,0.0006855025,0.0001648882,0.007310741,0.001351592,0.0009752279,0.001021068,0.00001937265],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933615,0.001871679,0.002877031,0.0003040888,0.00002681266,0.00001237904,0.0007778764,0.00002272191,0.00074599],"genre_scores_gemma":[0.9990191,0.0001553859,0.0004332523,0.00004113854,0.000016119,0.000004094001,0.0002457812,0.000007185045,0.00007788809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005595176,"threshold_uncertainty_score":0.02959049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02025673690128002,"score_gpt":0.2862526297010806,"score_spread":0.2659958927998006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}