{"id":"W3144656479","doi":"10.1038/s41598-021-86268-1","title":"Hypoxia and oxidative stress induce sterile placental inflammation in vitro","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Institute of Human Development, Child and Youth Health; Medical Research Council; Canadian Institutes of Health Research; Tommy's; Natural Sciences and Engineering Research Council of Canada; Tommy's Baby Charity","keywords":"Oxidative stress; Inflammation; Hypoxia (environmental); Placenta; HMGB1; Biology; Proinflammatory cytokine; Endocrinology; Internal medicine; Immunology; Andrology; Fetus; Chemistry; Medicine; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004331719,0.0003712186,0.0004927407,0.0002728863,0.0001839846,0.0003847329,0.0002449079,0.0002450179,0.002396753],"category_scores_gemma":[0.0003158425,0.0002701076,0.0004390998,0.0002222923,0.0002139253,0.000198444,0.0003901411,0.0006943521,0.0005253707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002555882,"about_ca_system_score_gemma":0.0002370263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001074425,"about_ca_topic_score_gemma":0.001231887,"domain_scores_codex":[0.999594,0.00011299,0.00004095773,0.00007478598,0.00008203612,0.00009527154],"domain_scores_gemma":[0.9997376,0.00009503846,0.00005598464,0.00004630829,0.00002521734,0.00003979814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001169759,0.0002194924,0.0008876616,0.0003292948,0.000025014,0.0004247951,0.0002529616,0.0001939879,0.9924294,0.0001565434,0.0002522735,0.003658711],"study_design_scores_gemma":[0.0002210085,0.006207441,0.02393521,0.0001046934,0.000118028,0.001899981,0.0002567904,0.002560072,0.9517307,0.000436368,0.01250784,0.00002187642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9618995,0.02196458,0.006349423,0.000520065,0.0002286406,0.0001978785,0.001162566,0.0001202812,0.00755718],"genre_scores_gemma":[0.9832082,0.006983089,0.004080676,0.0002908952,0.0001105013,0.0001487549,0.001812651,0.00002021698,0.003344929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002396753,"threshold_uncertainty_score":0.008017957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01963817190094955,"score_gpt":0.2632173631412532,"score_spread":0.2435791912403036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}