{"id":"W3144689559","doi":"10.1016/j.etap.2021.103654","title":"Inflammatory response in human alveolar epithelial cells after TiO2 NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function","year":2021,"lang":"en","type":"article","venue":"Environmental Toxicology and Pharmacology","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"Consejo Nacional de Ciencia y Tecnología","keywords":"Pulmonary surfactant; Lung; Surfactant protein D; Chemistry; Human lung; Inflammation; Cell biology; Protein expression; Lung function; Function (biology); Surfactant protein A; A549 cell; Cancer research; Apoptosis; Immunology; Biochemistry; Biology; Medicine; Innate immune system; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001022618,0.0001764124,0.0004088579,0.0002114674,0.00009189323,0.000002714187,0.00006083048,0.000379057,0.002760201],"category_scores_gemma":[0.0000669952,0.0001642359,0.00006197547,0.00009332959,0.0004711628,0.0001361439,0.0001189223,0.0004073214,0.000008532486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001951122,"about_ca_system_score_gemma":0.0003090028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003808359,"about_ca_topic_score_gemma":0.00001080024,"domain_scores_codex":[0.9974738,0.0009341661,0.0005807343,0.0004305891,0.0002301964,0.0003504546],"domain_scores_gemma":[0.999052,0.0003062483,0.0002138444,0.0001784136,0.00002111887,0.0002283765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06472924,0.001050644,0.01667177,0.000623947,0.00004296101,0.0004689503,0.0003854652,0.000004362673,0.9149729,0.00001297498,0.00002870631,0.001008049],"study_design_scores_gemma":[0.006368828,0.005835829,0.09098276,0.0000640347,0.00004745432,0.00004257448,0.0001402453,0.00001505615,0.8929385,0.00006756208,0.003382335,0.0001148047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996986,0.0008305779,0.0000276288,0.0001783641,0.00014186,0.001678039,0.0001362654,0.00001040503,0.00001083078],"genre_scores_gemma":[0.9981588,0.0001570525,0.0001657155,0.0005637147,0.0000871947,0.000514853,0.00005421459,0.00002749407,0.0002709528],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.074311,"threshold_uncertainty_score":0.9981514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01806574351679092,"score_gpt":0.3380223730019924,"score_spread":0.3199566294852015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}