{"id":"W3145035817","doi":"","title":"Decrease of liposomal size and retarding effect on fluconazole skin permeation by lysine derivatives","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Permeation; Liposome; Chemistry; Vesicle; Transdermal; Chromatography; Drug carrier; Drug delivery; Fluconazole; Particle size; Membrane; Organic chemistry; Biochemistry; Pharmacology; Antifungal","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00252515,0.0003612796,0.0005671654,0.0002225465,0.0003667851,0.00002879225,0.0005861564,0.000116128,0.002691619],"category_scores_gemma":[0.0006080105,0.0002827336,0.0002105993,0.0004763283,0.001516001,0.0007861045,0.0001070475,0.0009687464,0.00001528619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007504198,"about_ca_system_score_gemma":0.000140604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001644715,"about_ca_topic_score_gemma":7.641135e-7,"domain_scores_codex":[0.9964082,0.0009779269,0.0009417161,0.0003905359,0.0006967004,0.0005849589],"domain_scores_gemma":[0.9964668,0.001911091,0.0005902509,0.0001086288,0.0002165444,0.0007066874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004885473,0.001123441,0.05611085,0.0001714279,0.0004071918,0.0001092345,0.001509639,0.0002442989,0.8026666,0.0004493815,0.0006943497,0.1316281],"study_design_scores_gemma":[0.005826552,0.001490114,0.00363063,0.00008655811,0.000520697,0.0001579455,0.0001914376,0.005406255,0.9529757,0.0002437377,0.02912797,0.0003423281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915455,0.003323535,0.0004439975,0.0005018839,0.0008131255,0.0003508828,0.00003974697,0.00002579391,0.002955507],"genre_scores_gemma":[0.9949329,0.001990872,0.00113278,0.001626423,0.0002268157,0.000009250051,0.00000207173,0.00002101676,0.00005782488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1503092,"threshold_uncertainty_score":0.9999625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1234775622576311,"score_gpt":0.4513712100284965,"score_spread":0.3278936477708653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}