{"id":"W3145200680","doi":"10.1038/nm.4449","title":"Reply to The small molecule CLP257 does not modify activity of the K+–Cl− co-transporter KCC2 but does potentiate GABAA receptor activity","year":2017,"lang":"en","type":"letter","venue":"Nature Medicine","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"","keywords":"GABAA receptor; Transporter; Chemistry; Receptor; Pharmacology; Biophysics; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001840116,0.0008488707,0.001149433,0.000439809,0.00192902,0.001954806,0.001268745,0.02606506,0.006173092],"category_scores_gemma":[0.01502775,0.0005179886,0.0008916805,0.0003227985,0.002365947,0.002014657,0.001123854,0.02993569,0.006589675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002385877,"about_ca_system_score_gemma":0.001622906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00130974,"about_ca_topic_score_gemma":0.001220235,"domain_scores_codex":[0.9989403,0.0002414577,0.0001577271,0.0001539751,0.0003660235,0.0001404289],"domain_scores_gemma":[0.9960541,0.002390117,0.000334645,0.0001458556,0.0006362336,0.0004391649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003275939,0.000110114,0.0004441637,0.0000986439,0.00002933648,0.002706968,0.0001083507,0.0001317859,0.0008279834,0.003177346,0.9818721,0.01016551],"study_design_scores_gemma":[0.0004712526,0.0004646279,0.002101266,0.0002265401,0.00009633683,0.003038169,0.0005415328,0.001414087,0.002888532,0.01669129,0.9719341,0.0001322377],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.0007863597,0.000977328,0.0001815928,0.9502911,0.04630977,0.00001289318,0.0001050845,0.00006517863,0.001270802],"genre_scores_gemma":[0.01184336,0.001949899,0.0003792126,0.895786,0.08009914,0.00007028691,0.00009621677,0.00005148399,0.009724341],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.02606506,"threshold_uncertainty_score":0.0206511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04268971849844926,"score_gpt":0.3442922829353973,"score_spread":0.3016025644369481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}