{"id":"W3145440970","doi":"10.1371/journal.ppat.1009523","title":"Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms","year":2021,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Allergy and Infectious Diseases; Saskatchewan Health Research Foundation; Canadian Institutes of Health Research; National Institute of General Medical Sciences; National Institutes of Health; National Science Foundation","keywords":"Deamination; Human immunodeficiency virus (HIV); Chemistry; Computational biology; Biology; Virology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001560895,0.0003314167,0.0002002386,0.000155707,0.00008892333,0.0002262747,0.000183852,0.0002142133,0.0007783852],"category_scores_gemma":[0.0001086774,0.00009462436,0.0002036942,0.0001228241,0.0001502762,0.0001567147,0.0001900592,0.0004187061,0.0003277361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001835986,"about_ca_system_score_gemma":0.0001201696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002844491,"about_ca_topic_score_gemma":0.0005674504,"domain_scores_codex":[0.9998616,0.00002629057,0.00001112886,0.00002385878,0.00004831492,0.00002889846],"domain_scores_gemma":[0.9998847,0.00002691866,0.00002771124,0.00002036319,0.00001340271,0.00002694018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000245634,0.00001274631,0.00006063959,0.00001263493,0.000002438321,0.000009594411,0.000002908433,0.00003896517,0.9991098,0.00004734697,0.000009534002,0.0006687852],"study_design_scores_gemma":[0.00001110663,0.0004055221,0.001272607,0.00000314059,0.00001221757,0.0001994808,0.000008210972,0.0004263615,0.9956398,0.00004982218,0.001968549,0.0000031286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919741,0.001506913,0.004669533,0.0000343557,0.00001769095,0.00003479507,0.0003061923,0.00006159658,0.001394775],"genre_scores_gemma":[0.9925787,0.0005150861,0.004856183,0.00003124788,0.00001123331,0.00002720869,0.0005049307,0.00001634712,0.00145911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007783852,"threshold_uncertainty_score":0.002603948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02216461195857224,"score_gpt":0.2459172330463868,"score_spread":0.2237526210878145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}