{"id":"W3145444607","doi":"10.3390/nano11040953","title":"Sesquiterpene-Loaded Co-Polymer Hybrid Nanoparticle Effects on Human Mast Cell Surface Receptor Expression, Granule Contents, and Degranulation","year":2021,"lang":"en","type":"article","venue":"Nanomaterials","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; National Institute for Nanotechnology; University of Alberta","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"PLGA; Degranulation; Biocompatibility; Materials science; Polyvinyl alcohol; Mast cell; Chemistry; Biophysics; Nanoparticle; Nanotechnology; Receptor; Biochemistry; Organic chemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001860139,0.0003786056,0.0002322291,0.000107502,0.00006292621,0.0001667295,0.0001163431,0.0002342426,0.001057054],"category_scores_gemma":[0.000129708,0.0001161579,0.0002113527,0.00009165459,0.0001209805,0.000212151,0.0001071016,0.0003121536,0.0002351999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001504589,"about_ca_system_score_gemma":0.00009579836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003302015,"about_ca_topic_score_gemma":0.0004118122,"domain_scores_codex":[0.9999083,0.00001694295,0.00001206936,0.00002451229,0.00001546795,0.00002271851],"domain_scores_gemma":[0.9999186,0.00003526599,0.00001221115,0.000009411211,0.00001018482,0.00001440687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002545946,0.00005613921,0.00005178834,0.00003696158,0.000005741017,0.00004511975,0.00001481227,0.00007933571,0.9983162,0.00002263372,0.00002295868,0.001093819],"study_design_scores_gemma":[0.00003062068,0.0005167782,0.0008001034,0.000002008328,0.00001660969,0.00005516113,0.000006910101,0.0007526109,0.9974305,0.00001076019,0.000374793,0.000003026975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997612,0.0007952069,0.0008490879,0.00003903151,0.00002094992,0.00002042208,0.0001041093,0.00003339554,0.0005258351],"genre_scores_gemma":[0.9964938,0.0006186116,0.001115764,0.00004069227,0.00001409553,0.00004238463,0.000182201,0.00001182911,0.001480725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001057054,"threshold_uncertainty_score":0.003536224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599429975181186,"score_gpt":0.2453857283603415,"score_spread":0.2293914286085297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}