{"id":"W3145547372","doi":"10.1101/2021.04.08.435504","title":"Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Syddansk Universitet; National Institutes of Health; University of Alberta; Allegheny Health Network","keywords":"Exocytosis; Cell; Cell biology; Cell type; Biology; Type 2 diabetes; Endocrinology; Internal medicine; Receptor; Secretion; Diabetes mellitus; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002902259,0.0002027693,0.0003447623,0.0002986669,0.0001570656,0.0005439076,0.0001419959,0.0002159898,0.001433078],"category_scores_gemma":[0.0004459766,0.0001184076,0.0003597888,0.0003348141,0.0001963645,0.0002226362,0.0003013725,0.0003668836,0.0003312515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001355404,"about_ca_system_score_gemma":0.0000878943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000357099,"about_ca_topic_score_gemma":0.0004006776,"domain_scores_codex":[0.999783,0.00002199451,0.00002010888,0.00008922433,0.00005475542,0.00003097591],"domain_scores_gemma":[0.9996556,0.00007149866,0.00012925,0.00005137557,0.00004258652,0.00004968751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000675057,0.00003184079,0.05667172,0.00008551362,0.0001021044,0.0002116474,0.00008534416,0.000553979,0.9342845,0.00009812604,0.0001588698,0.007041223],"study_design_scores_gemma":[0.00001533213,0.0002896785,0.8475615,0.00002585942,0.0001278835,0.001371943,0.0001797475,0.00588853,0.1422425,0.0005020747,0.001771667,0.0000231989],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935148,0.0005298295,0.004452887,0.00004219981,0.00001161997,0.00000784175,0.001008674,0.00005646996,0.0003757324],"genre_scores_gemma":[0.9972137,0.000181768,0.001236598,0.00004513565,0.000006419423,0.00001098417,0.0009848585,0.00002008586,0.0003004855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001433078,"threshold_uncertainty_score":0.004794121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117335621920931,"score_gpt":0.2132066939344743,"score_spread":0.202033337715265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}