{"id":"W3145607668","doi":"10.3390/v13040581","title":"RNA Interference Therapy for Chronic Hepatitis B Predicts the Importance of Addressing Viral Integration When Developing Novel Cure Strategies","year":2021,"lang":"en","type":"review","venue":"Viruses","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"","keywords":"HBsAg; Hepatitis B virus; RNA interference; Medicine; Virus; Virology; RNA; Chronic infection; Chronic hepatitis; Viral load; Hepatitis B; Hepatitis C virus; Immunology; Biology; Gene; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006996879,0.0005741477,0.001114715,0.001382882,0.0002038077,0.0007822027,0.0006721561,0.001035022,0.004297555],"category_scores_gemma":[0.000941878,0.0001538074,0.0005738917,0.0009949631,0.000455919,0.001136373,0.000460307,0.002325812,0.002060613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004883552,"about_ca_system_score_gemma":0.0009022885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007592234,"about_ca_topic_score_gemma":0.001293104,"domain_scores_codex":[0.9997886,0.000059297,0.0000265711,0.00003058624,0.00007571338,0.00001925202],"domain_scores_gemma":[0.9996382,0.0001988503,0.00003908975,0.00001508842,0.0000855885,0.00002314746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001068229,0.00006326698,0.0001318648,0.02398621,0.000106468,0.0001419324,0.00005734729,0.0003377563,0.002501309,0.006794447,0.03024946,0.9355232],"study_design_scores_gemma":[0.00002126207,0.0001333547,0.0005954411,0.007491571,0.0001244689,0.0009658951,0.00005115562,0.00009024902,0.000509157,0.002907963,0.9870969,0.00001264918],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009185264,0.9983128,0.00009532736,0.0003947089,0.0002318147,0.00000375985,0.00001268234,0.000006515324,0.0008504578],"genre_scores_gemma":[0.0006644559,0.9981109,0.0001689689,0.0003197526,0.0001462935,0.000005932303,0.00001984409,0.000001786761,0.0005620949],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004297555,"threshold_uncertainty_score":0.01437676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2114863730519554,"score_gpt":0.4101121537226212,"score_spread":0.1986257806706658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}