{"id":"W3145607668","doi":"10.3390/v13040581","title":"RNA Interference Therapy for Chronic Hepatitis B Predicts the Importance of Addressing Viral Integration When Developing Novel Cure Strategies","year":2021,"lang":"en","type":"review","venue":"Viruses","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"","keywords":"HBsAg; Hepatitis B virus; RNA interference; Medicine; Virus; Virology; RNA; Chronic infection; Chronic hepatitis; Viral load; Hepatitis B; Hepatitis C virus; Immunology; Biology; Gene; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003124974,0.0005317857,0.001922881,0.0001461354,0.0001949463,0.0001147606,0.000332988,0.0002680129,0.0000665823],"category_scores_gemma":[0.0004525292,0.0003277535,0.0004115885,0.000268351,0.0002513109,0.00029204,0.0001365643,0.0004591019,0.000004640252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003827096,"about_ca_system_score_gemma":0.002879429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007902847,"about_ca_topic_score_gemma":0.005585588,"domain_scores_codex":[0.9976177,0.0001215346,0.001060482,0.000500997,0.0003365139,0.0003627909],"domain_scores_gemma":[0.9976807,0.0005145372,0.0008094201,0.0005342905,0.0004113772,0.00004968781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003065622,0.00008075904,0.0008279145,0.01330721,0.0009327032,0.00001126781,0.001057415,7.499382e-7,0.000284554,0.003602913,0.00258732,0.9772766],"study_design_scores_gemma":[0.0006338774,0.000489783,0.0003501486,0.09782714,0.0007664555,0.00003443162,0.0001395509,0.00004089569,0.001072002,0.0002576631,0.897926,0.0004621144],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003970819,0.9862964,0.01024893,0.000140802,0.0004225404,0.001836554,0.000371024,0.00007115637,0.0002155776],"genre_scores_gemma":[0.001745984,0.9927804,0.003511893,0.0003481227,0.0005660426,0.00067917,0.0002238104,0.00008562412,0.00005890708],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9768144,"threshold_uncertainty_score":0.9999174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2114863730519554,"score_gpt":0.4101121537226212,"score_spread":0.1986257806706658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}