{"id":"W3145621337","doi":"10.3390/membranes11040247","title":"The Antimicrobial Peptide Gramicidin S Enhances Membrane Adsorption and Ion Pore Formation Potency of Chemotherapy Drugs in Lipid Bilayers","year":2021,"lang":"en","type":"article","venue":"Membranes","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"King Saud University; University of Alberta","keywords":"Gramicidin; Membrane; Chemistry; Lipid bilayer; Gramicidin S; Alamethicin; Liposome; POPC; Biophysics; Aqueous solution; Peptide; Bilayer; Adsorption; Antimicrobial peptides; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002051868,0.000312031,0.0002456954,0.0001655383,0.00009309771,0.0002738898,0.0001666388,0.000287747,0.0005326587],"category_scores_gemma":[0.0002832389,0.00009837509,0.0001643938,0.0001004613,0.0003511325,0.0002561275,0.0002705833,0.0003588466,0.0001695237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002061876,"about_ca_system_score_gemma":0.0001011884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003998703,"about_ca_topic_score_gemma":0.0003740027,"domain_scores_codex":[0.9998029,0.00005258009,0.00001571054,0.00004143053,0.00005337785,0.00003399134],"domain_scores_gemma":[0.999821,0.00006808017,0.00003892599,0.00001918823,0.00002711766,0.00002562859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002320145,0.000002787536,0.00003216586,0.00001502198,9.674548e-7,0.00001411342,0.000006522717,0.000008925706,0.9995599,0.000009880572,0.000003154345,0.0003232917],"study_design_scores_gemma":[0.000002595522,0.0000740654,0.000579398,8.741881e-7,0.000002441897,0.00003563359,0.000006820573,0.0002002856,0.9988962,0.00000754039,0.0001926381,0.000001364047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951268,0.001243509,0.002754479,0.000114959,0.00001488737,0.00002255437,0.00005506271,0.00004784707,0.0006198636],"genre_scores_gemma":[0.9962986,0.0006315106,0.002370269,0.00005119987,0.000008520593,0.00001142823,0.00005417804,0.00001097053,0.0005633716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005326587,"threshold_uncertainty_score":0.00178194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005466872646502207,"score_gpt":0.228187251502989,"score_spread":0.2227203788564868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}