{"id":"W3145804410","doi":"10.3390/cancers13071705","title":"IL15RA and SMAD3 Genetic Variants Predict Overall Survival in Metastatic Colorectal Cancer Patients Treated with FOLFIRI Therapy: A New Paradigm","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"FOLFIRI; Irinotecan; Colorectal cancer; Oncology; Medicine; Internal medicine; Fluorouracil; Chemotherapy; Cetuximab; Immune system; Cancer; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006833891,0.0002510848,0.0003610032,0.0003340967,0.0001760367,0.0004238692,0.0002601877,0.0003271053,0.0008950193],"category_scores_gemma":[0.001081153,0.0001031674,0.0004795175,0.0003872795,0.0002449305,0.000239332,0.0002449768,0.0003993448,0.00011145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001436004,"about_ca_system_score_gemma":0.0001982532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001091796,"about_ca_topic_score_gemma":0.00194765,"domain_scores_codex":[0.9997675,0.00007832803,0.00002012229,0.00007500962,0.00003094914,0.00002804471],"domain_scores_gemma":[0.9993836,0.0001960712,0.000217642,0.00008093284,0.00003937226,0.00008246316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001055031,0.00002854302,0.9899928,0.00001829502,0.000200225,0.00008551346,0.0000513938,0.0001565348,0.00295501,0.00004508869,0.0000991407,0.005312518],"study_design_scores_gemma":[0.00003208281,0.0002283022,0.9971837,0.00001035896,0.000216105,0.0003006582,0.00008298981,0.0009620388,0.0004272962,0.0001424446,0.0004084259,0.000005598034],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985417,0.0008296141,0.000227696,0.0001080909,0.000006694074,0.000003934579,0.0001111955,0.000003286567,0.0001678763],"genre_scores_gemma":[0.9994372,0.0001339668,0.0001629021,0.00003567387,0.00001663591,0.000003106195,0.0001368099,0.000001303039,0.00007237539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001091796,"threshold_uncertainty_score":0.003614128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0188651546298749,"score_gpt":0.2587461337020068,"score_spread":0.2398809790721319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}