{"id":"W3146122039","doi":"10.1016/s2213-8587(21)00046-2","title":"Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":226,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials; Université de Montréal","funders":"Akebia Therapeutics; Ionis Pharmaceuticals","keywords":"Medicine; Placebo; Clinical trial; Internal medicine; Triglyceride; Dosing; Randomized controlled trial; Surgery; Physical therapy; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001628294,0.002395571,0.00369376,0.0004565317,0.0005169442,0.001495682,0.0009391427,0.002279583,0.006822517],"category_scores_gemma":[0.001354831,0.0006798083,0.003289326,0.0004348255,0.001368728,0.001333451,0.0005922582,0.003423485,0.001244511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00060749,"about_ca_system_score_gemma":0.0009166857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009355641,"about_ca_topic_score_gemma":0.002033126,"domain_scores_codex":[0.9995017,0.0002194863,0.00003205811,0.0001008179,0.00004088991,0.0001050911],"domain_scores_gemma":[0.9992419,0.0001656799,0.0001870479,0.00005624655,0.00004886682,0.0003002565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9886946,0.001613522,0.0005783491,0.0004481181,0.000939355,0.00003706985,0.0000462874,0.0001421949,0.001496832,0.00006551701,0.000454634,0.00548353],"study_design_scores_gemma":[0.9664748,0.03073844,0.001653287,0.00002991356,0.0003839735,0.00002670292,0.00002486405,0.0001247797,0.0001565315,0.00008207199,0.0002901149,0.00001443174],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879463,0.006936653,0.0004168022,0.0007699282,0.0005260257,0.001126616,0.0008488811,0.0001195508,0.001309313],"genre_scores_gemma":[0.9859633,0.004118249,0.001063739,0.001480546,0.0005627793,0.001720719,0.001613003,0.00003458403,0.003443134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006822517,"threshold_uncertainty_score":0.02282363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122362333717553,"score_gpt":0.2868707706200514,"score_spread":0.2656471472828759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}