{"id":"W3146122039","doi":"10.1016/s2213-8587(21)00046-2","title":"Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":226,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Robarts Clinical Trials; Université de Montréal","funders":"Akebia Therapeutics; Ionis Pharmaceuticals","keywords":"Medicine; Placebo; Clinical trial; Internal medicine; Triglyceride; Dosing; Randomized controlled trial; Surgery; Physical therapy; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003482992,0.0002929489,0.001752474,0.0001228691,0.00006460291,0.0000175773,0.000169331,0.0001122936,0.0001126661],"category_scores_gemma":[0.0004526237,0.0001810445,0.000123226,0.0001956413,0.000243955,0.00006701479,0.000100391,0.0003776021,0.000008613712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003237487,"about_ca_system_score_gemma":0.0001430682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005659366,"about_ca_topic_score_gemma":0.00006896974,"domain_scores_codex":[0.9974802,0.0003235925,0.0006295725,0.0004080716,0.0002373154,0.0009213217],"domain_scores_gemma":[0.9980113,0.0009544285,0.0002512954,0.0005303965,0.0001369067,0.0001156991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9214199,0.001370381,0.07124279,0.00006399721,0.0004519865,0.00001566017,0.0003696407,0.00001723182,0.0009661269,0.000123393,0.000132612,0.003826317],"study_design_scores_gemma":[0.9626601,0.0005803218,0.0305043,0.00004938658,0.0005328946,0.000003374039,0.00009656799,0.00007121739,0.002091822,0.00001514441,0.003213409,0.0001815106],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929967,0.001022962,0.00000440312,0.0005932818,0.0007628819,0.004177735,0.00004364847,0.00003809647,0.0003602779],"genre_scores_gemma":[0.9981174,0.0002240021,0.00015325,0.0002600203,0.0007996112,0.0001912283,0.0001636339,0.00002858047,0.00006223933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04124019,"threshold_uncertainty_score":0.738278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122362333717553,"score_gpt":0.2868707706200514,"score_spread":0.2656471472828759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}