{"id":"W3146190083","doi":"10.21203/rs.3.rs-223104/v1","title":"Synthesis, characterization and antimicrobial properties of two derivatives of pyrrolidine-2,5-dione fused at positions-3,4 to a dibenzobarrelene backbone","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Deutscher Akademischer Austauschdienst","keywords":"Chemistry; Antimicrobial; Pyrrolidine; Aniline; Stereochemistry; Proton NMR; Chemical structure; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009651688,0.0002930902,0.000678302,0.0004275239,0.0003205982,0.00005474012,0.0003253425,0.0003620888,0.0004657105],"category_scores_gemma":[0.0002855513,0.0002756882,0.0001459085,0.0003555487,0.0005667548,0.0001062391,0.001518377,0.0009092993,0.00001076937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001346148,"about_ca_system_score_gemma":0.000263482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009102765,"about_ca_topic_score_gemma":0.00005158927,"domain_scores_codex":[0.9965164,0.001451571,0.0005417332,0.00058692,0.0004281113,0.0004752646],"domain_scores_gemma":[0.9978278,0.0002844865,0.0002510212,0.0003535004,0.001056799,0.0002263559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008020789,0.0007291186,0.01202331,0.002545613,0.0003149789,0.00002311883,0.001713946,0.0000652751,0.9800553,0.00007140989,0.0002309994,0.001424799],"study_design_scores_gemma":[0.0006977629,0.0001426582,0.03981218,0.001689666,0.00008391197,0.00001194422,0.0002649829,0.0003514056,0.9560165,0.00001407447,0.0006637708,0.0002510823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949018,0.001008611,0.0001963223,0.001475663,0.0003053579,0.001115725,0.0008562581,0.00002759532,0.0001126602],"genre_scores_gemma":[0.9963831,0.002330006,0.0002760298,0.00009251855,0.0001550924,0.0001655025,0.000310151,0.00003983279,0.000247779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02778887,"threshold_uncertainty_score":0.9999695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2191027899252277,"score_gpt":0.467265804241969,"score_spread":0.2481630143167413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}