{"id":"W3146237634","doi":"10.1161/circ.142.suppl_3.15751","title":"Abstract 15751: Pharmacodynamic Effect of ARO-ANG3, an Investigational RNA Interference Targeting Hepatic Angiopoietin-like Protein 3, in Patients With Hypercholesterolemia","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Université de Montréal; Université du Québec à Chicoutimi","funders":"","keywords":"Medicine; PCSK9; Placebo; Pharmacodynamics; Internal medicine; Triglyceride; Familial hypercholesterolemia; Statin; Endocrinology; Lipoprotein; Gastroenterology; Cholesterol; Pharmacology; Pharmacokinetics; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003227185,0.0004106747,0.0007650827,0.0001475447,0.000168033,0.0002427086,0.0001764542,0.0004583367,0.001672201],"category_scores_gemma":[0.0005056797,0.0001488771,0.0003659059,0.0001075787,0.0002859037,0.0002167576,0.0001311862,0.0007305566,0.0002734603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002233565,"about_ca_system_score_gemma":0.0002550556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003046238,"about_ca_topic_score_gemma":0.000750747,"domain_scores_codex":[0.9998395,0.000075105,0.00001483724,0.00002474077,0.00002051063,0.00002525845],"domain_scores_gemma":[0.9997895,0.00006092566,0.000055849,0.00001150502,0.00001070007,0.00007143585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5811014,0.02282028,0.03296366,0.0004978604,0.0008534018,0.00110736,0.0002261913,0.001015613,0.223209,0.0001321558,0.001743597,0.1343296],"study_design_scores_gemma":[0.1482191,0.6167443,0.2025336,0.00004205573,0.0009643739,0.001319836,0.0001396207,0.00245749,0.02451401,0.0001374094,0.002876443,0.00005155445],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984877,0.0005528797,0.0001418368,0.00008599205,0.00001971712,0.00008317667,0.0001090126,0.00002161692,0.000498049],"genre_scores_gemma":[0.9987017,0.0001941889,0.0003222351,0.0001580045,0.00003623057,0.00008678169,0.000157168,0.000002876341,0.0003408945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672201,"threshold_uncertainty_score":0.005594075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141284789365011,"score_gpt":0.2421738278126913,"score_spread":0.2307609799190412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}