{"id":"W3146237634","doi":"10.1161/circ.142.suppl_3.15751","title":"Abstract 15751: Pharmacodynamic Effect of ARO-ANG3, an Investigational RNA Interference Targeting Hepatic Angiopoietin-like Protein 3, in Patients With Hypercholesterolemia","year":2020,"lang":"en","type":"article","venue":"Circulation","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Université de Montréal; Université du Québec à Chicoutimi","funders":"","keywords":"Medicine; PCSK9; Placebo; Pharmacodynamics; Internal medicine; Triglyceride; Familial hypercholesterolemia; Statin; Endocrinology; Lipoprotein; Gastroenterology; Cholesterol; Pharmacology; Pharmacokinetics; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005185,0.0001557868,0.0002765696,0.00009923692,0.00002717927,0.00001195861,0.00007321849,0.00006276521,0.00004191533],"category_scores_gemma":[0.0002101997,0.0001297539,0.00004440477,0.0002582715,0.0000595124,0.0002902627,0.00001735325,0.000176603,0.00001014976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003993664,"about_ca_system_score_gemma":0.00007394942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000485728,"about_ca_topic_score_gemma":0.000004241414,"domain_scores_codex":[0.9988315,0.00009229237,0.0003411864,0.0002695205,0.0003067057,0.0001587638],"domain_scores_gemma":[0.9994224,0.0000403533,0.0001692358,0.0001285839,0.00009281321,0.0001466298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004646035,0.0001032845,0.8825995,0.0003627875,0.00001845128,0.000001570035,0.0006704421,0.0006810319,0.1123733,0.00001257615,0.000009003378,0.002703474],"study_design_scores_gemma":[0.003433777,0.0002786851,0.9831005,0.0002566476,0.00006208228,3.939449e-7,0.00003793811,0.00775979,0.004914468,0.00002316286,0.000007196968,0.0001253977],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984648,0.00004206443,0.0002181692,0.000172724,0.00005865756,0.0008911029,0.00000838265,0.00003853305,0.0001055778],"genre_scores_gemma":[0.9989033,9.967216e-7,0.0003738821,0.0002359863,0.00007426622,0.00003091228,0.0003567042,0.00002262058,0.000001278476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1074589,"threshold_uncertainty_score":0.5291212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01141284789365011,"score_gpt":0.2421738278126913,"score_spread":0.2307609799190412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}