{"id":"W3146762921","doi":"10.1016/j.jtct.2021.03.029","title":"National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIb. The 2020 Preemptive Therapy Working Group Report","year":2021,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; British Columbia Children's Hospital; CancerCare Manitoba","funders":"Pharmacyclics; Universität Hamburg; Meiji Seika Pharma; Compass Therapeutics; Syndax Pharmaceuticals; CTI Biopharma; Alvin J. Siteman Cancer Center; Jazz Pharmaceuticals; National Institutes of Health; Regeneron Pharmaceuticals; Omeros Corporation; Anthony Nolan; Huntsman Cancer Institute; Takeda Pharmaceuticals U.S.A.; Massachusetts General Hospital; University of Minnesota; Janssen Pharmaceuticals; Memorial Sloan-Kettering Cancer Center; University at Buffalo; AbbVie; Clinical Science Research and Development; Universidad de Sevilla; National Cancer Institute; Gilead Sciences; Dana-Farber Cancer Institute; Roche; Novartis; Celgene; Bristol-Myers Squibb; AstraZeneca; CareDx; Incyte; Pfizer; Amgen; U.S. Department of Veterans Affairs","keywords":"Medicine; Graft-versus-host disease; Intensive care medicine; Clinical trial; Disease; Hematopoietic stem cell transplantation; Hematopoietic cell; Psychological intervention; Transplantation; Malignancy; Immunology; Internal medicine; Haematopoiesis; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00509806,0.000192588,0.0006206165,0.00009469411,0.0001288654,0.00002392352,0.00005760047,0.00009188538,0.00003453585],"category_scores_gemma":[0.0001691158,0.0001392794,0.0001704601,0.0002069989,0.0001091212,0.00003439904,0.000002625849,0.0001530229,0.000001116464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009539304,"about_ca_system_score_gemma":0.001697687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001779515,"about_ca_topic_score_gemma":0.00004988564,"domain_scores_codex":[0.996529,0.001025453,0.001439218,0.0003955562,0.0004134999,0.0001972165],"domain_scores_gemma":[0.9972702,0.001850534,0.0004936234,0.0001607661,0.0001447673,0.00008012767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2121216,0.007137903,0.1022291,0.01053894,0.005365645,0.003418923,0.06595068,0.0001619696,0.2359987,0.01476954,0.001801308,0.3405056],"study_design_scores_gemma":[0.1395064,0.004901284,0.5639795,0.006964775,0.0005292071,0.0006018757,0.002650327,0.001726649,0.2239483,0.0006788389,0.0531664,0.001346459],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766769,0.008733793,0.007667392,0.002525303,0.0005899548,0.003401613,0.00008047879,0.00003803555,0.000286521],"genre_scores_gemma":[0.9702622,0.02527855,0.002151715,0.0004879233,0.0002054972,0.0002579637,0.001261853,0.0000265472,0.0000677524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4617504,"threshold_uncertainty_score":0.567965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2873942891593231,"score_gpt":0.4623925765223438,"score_spread":0.1749982873630206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}