{"id":"W3146811394","doi":"10.1158/2159-8290.cd-20-1503","title":"Synthetic Lethality in Cancer Therapeutics: The Next Generation","year":2021,"lang":"en","type":"review","venue":"Cancer Discovery","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada); Amgen (Canada); Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Cancer Institute; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; Breast Cancer Research Foundation","keywords":"Druggability; Synthetic lethality; CRISPR; Computational biology; Suppressor; Carcinogenesis; Biology; Loss function; Drug discovery; Drug development; Function (biology); Gene; Phenotype; Cancer research; Bioinformatics; Drug; DNA repair; Genetics; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001415298,0.0009711476,0.001394628,0.001750028,0.0002898056,0.00127293,0.001206262,0.001814979,0.003138175],"category_scores_gemma":[0.0009873713,0.0004234498,0.0007242116,0.001173761,0.001262239,0.002319836,0.001112819,0.004043439,0.001865911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001325951,"about_ca_system_score_gemma":0.001117884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008277648,"about_ca_topic_score_gemma":0.001364966,"domain_scores_codex":[0.999571,0.0001083276,0.00003799787,0.0000608851,0.000166518,0.00005531527],"domain_scores_gemma":[0.9994441,0.000341808,0.00005114298,0.00002363884,0.00009097297,0.00004836831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001296575,0.0001166608,0.0001354617,0.01059391,0.0001218767,0.0003267694,0.00009869214,0.001088893,0.006142196,0.03409991,0.04247121,0.9046747],"study_design_scores_gemma":[0.0000266362,0.0001639553,0.0001997355,0.001188421,0.00004752148,0.0008560144,0.00003017082,0.000161358,0.00123606,0.005555014,0.9905143,0.00002074766],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001884473,0.9958473,0.0008463041,0.000912282,0.0002886062,0.000009575439,0.00002007744,0.00002544072,0.001861911],"genre_scores_gemma":[0.001938161,0.9947865,0.0008395003,0.0009462793,0.0002621346,0.00002515286,0.00004577433,0.000007383552,0.001149074],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003138175,"threshold_uncertainty_score":0.01049829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1006643734273958,"score_gpt":0.4061631181182451,"score_spread":0.3054987446908493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}