{"id":"W3146811394","doi":"10.1158/2159-8290.cd-20-1503","title":"Synthetic Lethality in Cancer Therapeutics: The Next Generation","year":2021,"lang":"en","type":"review","venue":"Cancer Discovery","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada); Amgen (Canada); Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Cancer Institute; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; Breast Cancer Research Foundation","keywords":"Druggability; Synthetic lethality; CRISPR; Computational biology; Suppressor; Carcinogenesis; Biology; Loss function; Drug discovery; Drug development; Function (biology); Gene; Phenotype; Cancer research; Bioinformatics; Drug; DNA repair; Genetics; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001452683,0.0002864129,0.0005041086,0.00003195737,0.00004708442,0.0001019072,0.0002533658,0.0002380882,0.00004181308],"category_scores_gemma":[0.00001453297,0.0002012718,0.0002852832,0.0001443657,0.00005201135,0.000005778892,0.0001062303,0.0002229747,0.000002465948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009776773,"about_ca_system_score_gemma":0.0005104104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001740405,"about_ca_topic_score_gemma":0.0007126686,"domain_scores_codex":[0.9987402,0.0001291585,0.0003059615,0.0004707285,0.0001130873,0.0002408447],"domain_scores_gemma":[0.9992704,0.00002126569,0.0000966335,0.0005523707,0.0000300123,0.00002931745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003261009,0.00003426774,0.0000409914,0.002009553,0.000254403,0.000003854796,0.0000482658,0.001079721,0.003615414,0.0000363406,0.001001369,0.9918725],"study_design_scores_gemma":[0.00007435273,0.00001238958,0.00001390509,0.00174881,0.0002649133,0.000005813121,0.00002470864,0.00004395906,0.001588754,0.000002521748,0.9959394,0.0002804524],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008104453,0.9970561,0.0006929738,0.0000854254,0.000840785,0.0003201992,0.00009955349,0.000004887804,0.0000895886],"genre_scores_gemma":[0.001832896,0.9952324,0.00001353424,0.0002067986,0.001170876,0.0005394283,0.0002055444,0.00004906853,0.0007494261],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9949381,"threshold_uncertainty_score":0.8207626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1006643734273958,"score_gpt":0.4061631181182451,"score_spread":0.3054987446908493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}