{"id":"W3146881107","doi":"10.1101/2021.03.26.436670","title":"Recurrent chromosomal translocations in sarcomas create a mega-complex that mislocalizes NuA4/TIP60 to Polycomb target loci","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Toronto General Hospital; University Health Network; University of Toronto; Université de Montréal; Université Laval; Princess Margaret Cancer Centre; Centre hospitalier universitaire de Québec","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; University of Toronto; Compute Canada; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"PRC2; Biology; Chromosomal translocation; Chromatin; Polycomb-group proteins; Histone H3; Histone; Cell biology; EZH2; Fusion protein; Fusion gene; Cancer research; Transcription factor; Genetics; Gene; Repressor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343203,0.0003260476,0.0001299602,0.0002475341,0.0001676553,0.0002720107,0.0001618895,0.0003184859,0.00144642],"category_scores_gemma":[0.0001748038,0.0001637916,0.0002201302,0.0001424847,0.0002093455,0.0001685826,0.0004848006,0.0004020385,0.0005115002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004427915,"about_ca_system_score_gemma":0.0001157573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002771034,"about_ca_topic_score_gemma":0.000331472,"domain_scores_codex":[0.999844,0.00001659928,0.00001695902,0.00003402621,0.00005239493,0.0000360009],"domain_scores_gemma":[0.9998643,0.00001271982,0.00005119582,0.0000141839,0.00000894472,0.00004852761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000280069,0.00000634063,0.0007945063,0.00001312391,0.000006177568,0.0001700149,0.000009150373,0.00005410051,0.9981461,0.0001058893,0.00002952177,0.0006371544],"study_design_scores_gemma":[0.0000267772,0.0002327851,0.01878017,0.000008002587,0.000034702,0.004374729,0.00006400816,0.001881134,0.9682909,0.000155326,0.006145472,0.000006013358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964439,0.0003942809,0.00250385,0.00005530912,0.00001186534,0.00001173468,0.00009767907,0.00005761251,0.0004237317],"genre_scores_gemma":[0.9973763,0.0001301207,0.001285287,0.00001763956,0.000003145291,0.000008927568,0.0002644144,0.000009880618,0.0009042686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00144642,"threshold_uncertainty_score":0.004838765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02254531323093886,"score_gpt":0.2520222659965254,"score_spread":0.2294769527655865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}