{"id":"W3146945747","doi":"10.1016/j.ymthe.2021.04.008","title":"Gene therapy for ALS: A review","year":2021,"lang":"en","type":"review","venue":"Molecular Therapy","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":179,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; National Institute of Neurological Disorders and Stroke; Sächsische Aufbaubank; CHEO Research Institute","keywords":"Genetic enhancement; Biology; Gene; Computational biology; Genetics; Medicine; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000675928,0.0006710521,0.00361131,0.0001515746,0.00008009766,0.000055929,0.0004449605,0.0004385478,0.001207903],"category_scores_gemma":[0.0001303716,0.0004475531,0.002297285,0.0005372074,0.00007449662,0.00003250324,0.00007330213,0.0005583641,0.0001345979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000154141,"about_ca_system_score_gemma":0.0008336713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008591613,"about_ca_topic_score_gemma":1.44202e-7,"domain_scores_codex":[0.9964526,0.0005121679,0.0008106985,0.0008842269,0.0006938482,0.0006464486],"domain_scores_gemma":[0.9975933,0.0001324898,0.0002570395,0.00139665,0.0003461003,0.0002743778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003541787,0.0001680267,1.789879e-7,0.01818908,0.001105076,0.0002077388,0.000009081416,2.999493e-8,0.0004403352,0.00004182406,0.004969713,0.9748335],"study_design_scores_gemma":[0.001311216,0.0004653701,0.000001423038,0.05827969,0.0003809836,0.0001754528,4.92074e-7,8.545742e-7,0.00023653,0.00002700907,0.9387303,0.0003906892],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000009759164,0.990715,0.0003934107,0.001130243,0.0001236127,0.007230952,0.00004691643,0.00007627428,0.0002738924],"genre_scores_gemma":[6.602955e-7,0.9867415,0.001668271,0.006113307,0.0003202754,0.002626804,0.000910607,0.0002753268,0.001343178],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9744428,"threshold_uncertainty_score":0.9997976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1662840641686352,"score_gpt":0.4545602627584998,"score_spread":0.2882761985898646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}