{"id":"W3146945747","doi":"10.1016/j.ymthe.2021.04.008","title":"Gene therapy for ALS: A review","year":2021,"lang":"en","type":"review","venue":"Molecular Therapy","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":179,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; National Institute of Neurological Disorders and Stroke; Sächsische Aufbaubank; CHEO Research Institute","keywords":"Genetic enhancement; Biology; Gene; Computational biology; Genetics; Medicine; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008554787,0.00144546,0.002725892,0.003154255,0.0003152607,0.001457059,0.001319437,0.001880532,0.004949824],"category_scores_gemma":[0.0009944111,0.0003885901,0.0008336031,0.002862995,0.0005358005,0.001700608,0.001014512,0.002345916,0.002235885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006868551,"about_ca_system_score_gemma":0.001271457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159399,"about_ca_topic_score_gemma":0.002777802,"domain_scores_codex":[0.9997953,0.00003779787,0.00003421089,0.00003898201,0.00006837629,0.00002536881],"domain_scores_gemma":[0.9995645,0.0002405787,0.00006081669,0.000009386021,0.00007953444,0.00004529714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002498089,0.0001177903,0.0001194763,0.04900556,0.0002426217,0.0002471739,0.00005776327,0.0004693678,0.002158914,0.002175387,0.06512702,0.8800292],"study_design_scores_gemma":[0.0001499531,0.0002236492,0.0006407648,0.01241042,0.0006837748,0.001130482,0.00006698537,0.0001234973,0.0003889731,0.001610159,0.9825333,0.00003800994],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003352152,0.9993668,0.0000500093,0.0001090086,0.0001573472,0.000004236383,0.00001727226,0.000004886424,0.000256896],"genre_scores_gemma":[0.0002156201,0.999113,0.0001046877,0.0002012033,0.0001267387,0.000006055174,0.0000250594,0.000001056796,0.0002064924],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004949824,"threshold_uncertainty_score":0.01655889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1662840641686352,"score_gpt":0.4545602627584998,"score_spread":0.2882761985898646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}