{"id":"W3147077754","doi":"10.1101/2021.03.29.436986","title":"GCN5 Maintains Muscle Integrity by Acetylating YY1 to Promote Dystrophin Expression","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Ministry of Science and ICT, South Korea; École Polytechnique Fédérale de Lausanne; National Research Foundation; University of Ottawa; National Research Foundation of Korea; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"YY1; P300-CBP Transcription Factors; Zinc finger; PCAF; Dystrophin; Biology; Utrophin; Cell biology; Gene; Gene expression; Acetylation; Molecular biology; Genetics; Transcription factor; Promoter; Histone Acetyltransferases","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004891493,0.0003498379,0.0004168627,0.0004945109,0.0001750777,0.000469381,0.0002217716,0.0002078147,0.001700466],"category_scores_gemma":[0.0003799061,0.0001648742,0.0004343239,0.000559584,0.0002029357,0.0002543181,0.0004095809,0.0002899883,0.0005041206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004476206,"about_ca_system_score_gemma":0.0003406671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003325848,"about_ca_topic_score_gemma":0.005159927,"domain_scores_codex":[0.9996974,0.00003236714,0.00002038444,0.0001103521,0.00009385735,0.00004561144],"domain_scores_gemma":[0.9998085,0.00002596898,0.00006909617,0.00003605332,0.0000312125,0.00002912662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003604191,0.00001123224,0.02106209,0.0003406621,0.0002805446,0.00009338077,0.00005472824,0.0005813584,0.9653429,0.0003965881,0.0006693181,0.01080673],"study_design_scores_gemma":[0.00002978467,0.0001706887,0.3278809,0.00008587026,0.0003862904,0.0005012421,0.000147579,0.008188139,0.6416537,0.0009592982,0.01996764,0.00002895675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617531,0.01119089,0.01594582,0.0002761247,0.0001017786,0.00001954622,0.007974665,0.0004870556,0.002251039],"genre_scores_gemma":[0.9799885,0.001679558,0.006396177,0.0001320926,0.00002730745,0.00001718989,0.008730993,0.0001192691,0.002908866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003325848,"threshold_uncertainty_score":0.006612957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00951213636779921,"score_gpt":0.2298695318832651,"score_spread":0.2203573955154659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}