{"id":"W3147161883","doi":"10.1371/journal.pone.0248290","title":"CD40 signaling augments IL-10 expression and the tolerogenicity of IL-10-induced regulatory dendritic cells","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"CD40; Cell biology; Interleukin 10; Chemistry; Dendritic cell; Biology; Immunology; Cytokine; Immune system; Biochemistry; In vitro; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001773184,0.000536443,0.0003212864,0.0002319676,0.0001045379,0.0003642967,0.0001921084,0.0002508453,0.001561151],"category_scores_gemma":[0.0001344555,0.0001515242,0.0002454474,0.0001170547,0.0002069382,0.0001394389,0.0002053655,0.001023946,0.0005139254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002588496,"about_ca_system_score_gemma":0.0003449727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006252439,"about_ca_topic_score_gemma":0.001178848,"domain_scores_codex":[0.999656,0.0000591546,0.00002686025,0.00003516398,0.00007854159,0.0001443314],"domain_scores_gemma":[0.9997984,0.00003466213,0.00003547972,0.00001940755,0.00001760145,0.00009448249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001825598,0.0001000739,0.0001336082,0.00003649581,0.000002951905,0.00005693992,0.00001239773,0.00005251939,0.9984297,0.00003799552,0.00004870516,0.0009060135],"study_design_scores_gemma":[0.00007425954,0.001072015,0.005076369,0.00001529077,0.00002796021,0.0002859333,0.00004010975,0.0008209375,0.9891378,0.00005597418,0.00338765,0.000005685838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959551,0.0008960236,0.0006942808,0.0001142463,0.00006702761,0.00002844877,0.0002293607,0.00007269182,0.001942718],"genre_scores_gemma":[0.9954184,0.0006264364,0.0006950827,0.0001300236,0.0000359257,0.00003093981,0.0004582117,0.00002264434,0.002582316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001561151,"threshold_uncertainty_score":0.005222619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0277638095724876,"score_gpt":0.2217169371280489,"score_spread":0.1939531275555613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}