{"id":"W3147251563","doi":"10.1093/jnci/djx105","title":"RE: Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer","year":2017,"lang":"en","type":"letter","venue":"JNCI Journal of the National Cancer Institute","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Women's College Hospital; University of Toronto; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Germline; Prostate cancer; Germline mutation; Cancer; Kallikrein; Medicine; Genetics; Mutation; Oncology; Biology; Cancer research; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005029217,0.0005576135,0.0006157485,0.0006705517,0.0005564738,0.0006731203,0.0008641363,0.001987087,0.02937024],"category_scores_gemma":[0.006437212,0.0002532426,0.0007421463,0.0008603561,0.0003216567,0.0008263128,0.0003410838,0.002544163,0.002770204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002585048,"about_ca_system_score_gemma":0.0004139328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003357711,"about_ca_topic_score_gemma":0.00345608,"domain_scores_codex":[0.9993844,0.0001906595,0.00004401849,0.0001186746,0.0001353994,0.0001267888],"domain_scores_gemma":[0.998006,0.001163426,0.0002368511,0.00013016,0.0002807175,0.0001827371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003158544,0.0002764461,0.4941919,0.0004704808,0.001237038,0.0270727,0.0002168695,0.001110816,0.002217849,0.003779322,0.4237238,0.04254433],"study_design_scores_gemma":[0.001090357,0.0005268638,0.7883275,0.0007102027,0.001755259,0.07436728,0.001501421,0.01287731,0.00160406,0.01268819,0.1043892,0.0001623175],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5887391,0.0153831,0.006928918,0.2102746,0.02258226,0.0002674984,0.02889462,0.001013705,0.1259162],"genre_scores_gemma":[0.9450393,0.00183789,0.001339301,0.01118976,0.01146514,0.0001003588,0.003933259,0.00009742738,0.02499755],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.02937024,"threshold_uncertainty_score":0.09825325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07182054268076928,"score_gpt":0.3693194646206785,"score_spread":0.2974989219399092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}