{"id":"W3147281883","doi":"10.1093/noajnl/vdab024.066","title":"FSMP-01. ID1 MEDIATES ONE-CARBON MEDIATED PURINE SYNTHESIS IN GLIOBLASTOMA","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Medicinal Plant Pharmacodynamics Research","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Reprogramming; CD44; Biology; Cancer research; Carcinogenesis; Glioma; Purine; Purine metabolism; Knockout mouse; Enzyme; Molecular biology; Biochemistry; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001722527,0.0004938768,0.0009862075,0.000581127,0.0002113794,0.00002356062,0.0007664574,0.0007209227,0.004974897],"category_scores_gemma":[0.005188288,0.0005077119,0.0001326696,0.001250183,0.0006920393,0.0003076605,0.0003843788,0.00291749,0.0003514579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003179165,"about_ca_system_score_gemma":0.0006626234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002713937,"about_ca_topic_score_gemma":0.001235154,"domain_scores_codex":[0.9931815,0.002842,0.0009445483,0.001027839,0.0006446867,0.001359471],"domain_scores_gemma":[0.9849135,0.01350163,0.0003038371,0.0004074524,0.0002435138,0.0006300943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003454416,0.001835889,0.04198352,0.0003130097,0.0002708764,0.01092668,0.0004127851,0.001019532,0.8874957,0.0003687475,0.00193666,0.0499822],"study_design_scores_gemma":[0.005667487,0.0009303634,0.003694102,0.0001010617,0.0002808087,0.0007219811,0.0004496686,0.0176694,0.5598001,0.001018045,0.4088557,0.0008113168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567861,0.007213817,0.00001522623,0.0109073,0.003380905,0.0007054176,0.0001623375,0.0002456014,0.02058332],"genre_scores_gemma":[0.9743847,0.01880833,0.0002816153,0.004972554,0.0006504901,0.0004134719,0.00007144422,0.00007786293,0.0003395075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.406919,"threshold_uncertainty_score":0.9997374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08267362000674044,"score_gpt":0.437095646834014,"score_spread":0.3544220268272736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}