{"id":"W3147351247","doi":"10.1212/wnl.0000000000011848","title":"Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration","year":2021,"lang":"en","type":"article","venue":"Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of British Columbia; Western University","funders":"National Institute of Neurological Disorders and Stroke; NIHR Cambridge Biomedical Research Centre; Janssen Pharmaceuticals; Alzheimer Society of B.C.; Medical Research Council; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; National Institutes of Health; UK Dementia Research Institute; Eisai; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; Ionis Pharmaceuticals; Wolfson Foundation; National Institute on Aging; National Institute for Health and Care Research; Larry L. Hillblom Foundation; Genentech; AstraZeneca; National Brain Appeal; Wellcome Trust; Alzheimer Society; Alzheimer's Society; Deutsche Forschungsgemeinschaft; Eli Lilly and Company; Brain Research UK; TauRx Pharmaceuticals; Karolinska Institutet; EU Joint Programme – Neurodegenerative Disease Research; Little Family Foundation; Biogen","keywords":"Asymptomatic; Frontotemporal lobar degeneration; Medicine; Internal medicine; Asymptomatic carrier; Frontotemporal dementia; Oncology; Dementia; C9orf72; Disease; Gastroenterology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004040727,0.0007015601,0.0008673253,0.001070695,0.000233227,0.001066828,0.0005847848,0.001241617,0.001805609],"category_scores_gemma":[0.009442915,0.0002090811,0.0007759575,0.0004676954,0.0002799629,0.0004998296,0.0003049716,0.0005419576,0.000270645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004636898,"about_ca_system_score_gemma":0.0004437653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001692117,"about_ca_topic_score_gemma":0.002806995,"domain_scores_codex":[0.9987841,0.0005942383,0.0001124957,0.000236086,0.0002206866,0.00005233336],"domain_scores_gemma":[0.9945636,0.002786509,0.001589681,0.0001349348,0.0006555091,0.0002697763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03087593,0.0005713982,0.8901072,0.001424254,0.003661883,0.000107394,0.00008540017,0.0007396301,0.001080263,0.0001193073,0.001529196,0.06969809],"study_design_scores_gemma":[0.003789522,0.005586739,0.9729306,0.001588765,0.004377784,0.0004685403,0.0001237788,0.007824164,0.0008385165,0.0005458579,0.001879518,0.00004636713],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9410206,0.05309032,0.0009014961,0.0006528059,0.0001661698,0.0002157018,0.001373692,0.00004545303,0.002533807],"genre_scores_gemma":[0.995882,0.002320846,0.0007111036,0.0001367933,0.00008639385,0.0000600803,0.0004686744,0.000004051177,0.0003299466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004040727,"threshold_uncertainty_score":0.0213697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03071081125256068,"score_gpt":0.3039306990325005,"score_spread":0.2732198877799398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}