{"id":"W3147531120","doi":"10.1038/s41594-021-00674-7","title":"GPCR activation mechanisms across classes and macro/microscales","year":2021,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":308,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Novo Nordisk Fonden; European Commission; Canadian Institutes of Health Research; American Lebanese Syrian Associated Charities; Novo Nordisk; American Heart Association; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; H. Lundbeck A/S; Lundbeckfonden; National Science Foundation","keywords":"G protein-coupled receptor; Computational biology; Macro; Chemistry; Biology; Cell biology; Computer science; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001084497,0.0002708909,0.0002422894,0.00002978037,0.0001880397,0.00006556679,0.0001741716,0.0009001067,0.00007294557],"category_scores_gemma":[0.0001460035,0.0002386382,0.0001228927,0.000121835,0.000110587,0.000007172918,0.0002528718,0.0003813448,0.000002112601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001630938,"about_ca_system_score_gemma":0.00005968065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009026235,"about_ca_topic_score_gemma":0.00001765188,"domain_scores_codex":[0.9984571,0.0001334726,0.0002129065,0.0006788272,0.0001060603,0.0004116796],"domain_scores_gemma":[0.9992968,0.00001321973,0.00009974914,0.0003105903,0.0001818247,0.00009777695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004263207,0.000005839458,0.0001622455,0.0000134644,0.00006756355,0.0000140268,0.0000260862,0.000008205123,0.9802034,0.01570716,0.00008065066,0.003668677],"study_design_scores_gemma":[0.0004336588,0.000143765,0.0007960901,0.00001098857,0.00001459929,0.0001489341,0.0001097462,0.00002800592,0.9794689,0.013387,0.005172893,0.0002854288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9648768,0.002866605,0.030965,0.0004740493,0.0004979238,0.0001358275,0.00006266465,0.0000245745,0.00009653704],"genre_scores_gemma":[0.9877674,0.0001217742,0.009313256,0.00173542,0.00018159,0.00001017172,0.0006799093,0.00003263509,0.0001578699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02289055,"threshold_uncertainty_score":0.9731381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003868631346560044,"score_gpt":0.299291084618114,"score_spread":0.2954224532715539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}