{"id":"W3147565333","doi":"10.1007/s40263-021-00798-w","title":"Sphingosine 1-Phosphate Receptor Modulators for Multiple Sclerosis","year":2021,"lang":"en","type":"review","venue":"CNS Drugs","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Fingolimod; Sphingosine-1-phosphate receptor; S1PR1; Sphingosine-1-phosphate; Sphingosine kinase; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Pharmacology; Immune system; Medicine; Receptor; Sphingosine; Functional selectivity; Immunology; Neuroscience; Biology; G protein-coupled receptor; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003479107,0.000534791,0.001349713,0.00008434738,0.0001668653,0.00008694427,0.0004321116,0.0005689139,0.00005969106],"category_scores_gemma":[0.0003574609,0.0004894299,0.00106896,0.00022709,0.00005980453,0.000004939832,0.0002206167,0.0001949036,0.00003320312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000330822,"about_ca_system_score_gemma":0.0002915948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001586519,"about_ca_topic_score_gemma":0.000002403602,"domain_scores_codex":[0.9977934,0.00008964553,0.0005873373,0.0008736792,0.0001675983,0.0004883681],"domain_scores_gemma":[0.9985347,0.00007179817,0.0003097553,0.0007531863,0.0001558933,0.0001746192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001778836,0.00008319971,0.000006626647,0.004535201,0.0004471951,0.000001083004,0.00006843023,0.00001302418,0.003486943,0.0001213667,0.01578384,0.9754353],"study_design_scores_gemma":[0.0004951878,0.00003112271,9.53671e-7,0.002629908,0.0004290772,0.00000423939,0.00002697117,0.00001384909,0.007040292,0.000004124439,0.9887767,0.0005475575],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007131381,0.9957139,0.0008599611,0.00001679248,0.001462359,0.0007731857,0.00034557,0.00003421688,0.00008089763],"genre_scores_gemma":[0.0002192298,0.9902314,0.002432299,0.0001323787,0.002075455,0.000339034,0.002925699,0.0001658072,0.001478697],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9748877,"threshold_uncertainty_score":0.9997557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05276628998028735,"score_gpt":0.2955752716551384,"score_spread":0.242808981674851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}