{"id":"W3147565333","doi":"10.1007/s40263-021-00798-w","title":"Sphingosine 1-Phosphate Receptor Modulators for Multiple Sclerosis","year":2021,"lang":"en","type":"review","venue":"CNS Drugs","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Fingolimod; Sphingosine-1-phosphate receptor; S1PR1; Sphingosine-1-phosphate; Sphingosine kinase; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Pharmacology; Immune system; Medicine; Receptor; Sphingosine; Functional selectivity; Immunology; Neuroscience; Biology; G protein-coupled receptor; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005433583,0.001206024,0.001300991,0.00166291,0.000210379,0.0007433741,0.0008797471,0.001073782,0.004337849],"category_scores_gemma":[0.0006142424,0.000237551,0.0004254591,0.001721643,0.0004074698,0.0007999757,0.0005833727,0.002124203,0.002665845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004969765,"about_ca_system_score_gemma":0.0006886107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007547048,"about_ca_topic_score_gemma":0.002386384,"domain_scores_codex":[0.9998692,0.00002619467,0.00001703767,0.00002052223,0.00005112518,0.00001589255],"domain_scores_gemma":[0.9997993,0.00008208201,0.00003864772,0.000007791697,0.00004484941,0.00002736439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002135259,0.0001130362,0.0000850857,0.007600994,0.0000902934,0.0002479894,0.00002268081,0.0004316324,0.003289674,0.003195434,0.06231178,0.9223979],"study_design_scores_gemma":[0.00009354582,0.0001544861,0.0005171885,0.001421868,0.0001701534,0.0007908865,0.00001763379,0.0001329285,0.0007097802,0.001548537,0.9944293,0.00001359751],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001185884,0.9975981,0.0002314268,0.0003322939,0.0004445617,0.000008107231,0.0000321611,0.00001395027,0.001220883],"genre_scores_gemma":[0.0009563765,0.995908,0.000427873,0.0004267872,0.0004855014,0.00001612375,0.00006560338,0.000003244803,0.001710418],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004337849,"threshold_uncertainty_score":0.01451153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05276628998028735,"score_gpt":0.2955752716551384,"score_spread":0.242808981674851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}