{"id":"W3147746861","doi":"10.1002/chem.202100040","title":"Imide Condensation as a Strategy for the Synthesis of Core‐Diversified G‐Quadruplex Ligands with Anticancer and Antiparasitic Activity**","year":2021,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"European Research Council; Natural Sciences and Engineering Research Council of Canada; Engineering and Physical Sciences Research Council; Ministerio de Ciencia, Innovación y Universidades","keywords":"Chemistry; Antiparasitic; Selectivity; DNA; G-quadruplex; Imide; Combinatorial chemistry; Fluorescence; Stereochemistry; Oligonucleotide; Biophysics; Aptamer; Biochemistry; Biology; Molecular biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002144992,0.00075663,0.000377704,0.0003547326,0.0001619244,0.0002168881,0.0004244246,0.000370746,0.001454798],"category_scores_gemma":[0.0001828029,0.0002627404,0.0002183594,0.0003165811,0.0002301088,0.0003757848,0.000328095,0.0006167202,0.0008021008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003817826,"about_ca_system_score_gemma":0.0002552942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003139778,"about_ca_topic_score_gemma":0.0006856348,"domain_scores_codex":[0.9998425,0.0000289728,0.00001326869,0.00004516788,0.00003219398,0.00003794365],"domain_scores_gemma":[0.9999284,0.00001537371,0.000024991,0.000009700971,0.00001125806,0.00001027527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000877945,0.00007831687,0.00007622722,0.0001865982,0.00002150539,0.0001428259,0.00005139448,0.0008218702,0.986736,0.000815423,0.0003102633,0.01067178],"study_design_scores_gemma":[0.00002591521,0.0005245713,0.0002797909,0.000007720338,0.00001703387,0.000308397,0.000008234482,0.001293923,0.9898343,0.0001543937,0.007529414,0.00001629922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8093092,0.01244223,0.149529,0.0005551232,0.0002287997,0.001132428,0.001475294,0.001286873,0.02404095],"genre_scores_gemma":[0.9403547,0.004855545,0.04731695,0.00029886,0.00004982587,0.0003456787,0.0005802831,0.0001634008,0.006034821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001454798,"threshold_uncertainty_score":0.004866779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02216362212037061,"score_gpt":0.2561041118219485,"score_spread":0.2339404897015779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}