{"id":"W3147795917","doi":"10.1038/s41596-021-00500-w","title":"Assessing biofilm inhibition and immunomodulatory activity of small amounts of synthetic host defense peptides synthesized using SPOT-array technology","year":2021,"lang":"en","type":"article","venue":"Nature Protocols","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; Michael Smith Health Research BC; Government of Canada","keywords":"Peptide; Computational biology; Host (biology); Antimicrobial peptides; Protocol (science); Antimicrobial; Combinatorial chemistry; High-throughput screening; Biofilm; Biology; Chemistry; Bioinformatics; Microbiology; Medicine; Biochemistry; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003310535,0.0005046492,0.0002680539,0.0001401475,0.0001262972,0.000265769,0.0002171459,0.0003801557,0.0009235277],"category_scores_gemma":[0.0002630173,0.0001365617,0.0002470036,0.0001894891,0.0002018665,0.0002416847,0.0001579624,0.0008206559,0.0001700764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001418784,"about_ca_system_score_gemma":0.0001618016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001185925,"about_ca_topic_score_gemma":0.000294569,"domain_scores_codex":[0.9997506,0.0000409951,0.00001816591,0.00004222456,0.00009949129,0.00004854565],"domain_scores_gemma":[0.9997877,0.0001022777,0.0000356824,0.00001561,0.00003155617,0.00002718958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000420712,0.00001533688,0.00002327054,0.00001388197,0.000001842763,0.00000359539,0.00000280286,0.00003386024,0.9995481,0.00001070821,0.000005489597,0.0002989933],"study_design_scores_gemma":[0.000005510567,0.0002780058,0.0004844272,0.000001219112,0.000005590629,0.00001076594,0.00000458714,0.0004280108,0.9986332,0.00001073379,0.0001364726,0.000001528001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9877032,0.00110517,0.009866002,0.00006307244,0.00004793148,0.0000526467,0.0002507486,0.00004373015,0.0008674926],"genre_scores_gemma":[0.9759823,0.001205423,0.01978856,0.00009350842,0.00003186544,0.0001700778,0.0007047202,0.00002233039,0.002001122],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0009235277,"threshold_uncertainty_score":0.003089488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02039710501061395,"score_gpt":0.2857176054549915,"score_spread":0.2653205004443776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}