{"id":"W3147882607","doi":"","title":"Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations","year":2016,"lang":"en","type":"article","venue":"OECD series on adverse outcome pathways","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Health Canada","funders":"","keywords":"Germ cell; Biology; Context (archaeology); Germline; Adverse Outcome Pathway; Genetics; Meiosis; Mutation; Somatic cell; DNA damage; DNA; Gene; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002174042,0.0002955314,0.0003401331,0.0001910608,0.00006734658,0.000008916232,0.0002056345,0.0001671774,0.0001506624],"category_scores_gemma":[0.0001316411,0.0002557461,0.0001610032,0.0001368756,0.00005579899,0.00002197388,0.00009198862,0.0001031413,0.0002489779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008451121,"about_ca_system_score_gemma":0.00004739865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001574054,"about_ca_topic_score_gemma":0.0001233477,"domain_scores_codex":[0.9982624,0.00004848768,0.0005668714,0.0004745181,0.000228038,0.0004196853],"domain_scores_gemma":[0.9990606,0.00005333202,0.0001318997,0.0005513238,0.00005439098,0.0001483933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001935108,0.0001100186,0.0212276,0.00007149081,0.00002365885,0.00001807495,0.0002678381,0.01361228,0.9626715,0.0004998522,0.00009133119,0.001212907],"study_design_scores_gemma":[0.001293047,0.0007610251,0.02786547,0.0001065878,0.0000178354,0.000009308555,0.0003915988,0.00005806901,0.958755,0.00003694709,0.01022581,0.00047926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918802,0.00002370969,0.002759082,0.0001726384,0.0004241148,0.0004374859,0.0001514871,0.00003561515,0.004115697],"genre_scores_gemma":[0.9908252,0.00001852183,0.001295148,0.0001896159,0.00007391052,0.00004616032,0.00004257726,0.00005057859,0.007458243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01355421,"threshold_uncertainty_score":0.9999894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669297385173359,"score_gpt":0.2853784118132483,"score_spread":0.2686854379615147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}