{"id":"W3147918177","doi":"10.1002/prp2.758","title":"Effect of hepatic impairment on pharmacokinetics, safety, and tolerability of lemborexant","year":2021,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eisai","keywords":"Cmax; Tolerability; Pharmacokinetics; Medicine; Dosing; Adverse effect; Internal medicine; Gastroenterology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003261282,0.0002500141,0.0003378626,0.00008721843,0.00009912106,0.0002132685,0.00009599846,0.0001277645,0.001948185],"category_scores_gemma":[0.0003863972,0.00008938743,0.000174142,0.00007738025,0.0002323913,0.0002326103,0.000133216,0.0002722893,0.0001650651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002122161,"about_ca_system_score_gemma":0.0001860531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007641882,"about_ca_topic_score_gemma":0.001204189,"domain_scores_codex":[0.9998798,0.00005080309,0.000008853024,0.00001588505,0.00001708926,0.0000276534],"domain_scores_gemma":[0.9997635,0.00005837054,0.0000613232,0.00002274199,0.00002037743,0.00007359921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.377942,0.006799638,0.04514373,0.0004424739,0.0004731286,0.0005603809,0.0001628051,0.001259592,0.5023541,0.0001281488,0.00077975,0.06395427],"study_design_scores_gemma":[0.009054068,0.2909528,0.5590054,0.0000538692,0.0006903252,0.001101442,0.0003212791,0.003984828,0.1314463,0.0001637146,0.003181497,0.00004448206],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989817,0.0004558423,0.00009358527,0.00001461774,0.000005143068,0.00002755782,0.00009558583,0.00001200587,0.0003140724],"genre_scores_gemma":[0.9993992,0.00009794475,0.00006500931,0.0000344621,0.000005610492,0.0000147057,0.0001081921,0.000002371286,0.0002724717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001948185,"threshold_uncertainty_score":0.006517291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05375307269039491,"score_gpt":0.4452083302812825,"score_spread":0.3914552575908876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}