{"id":"W3147967992","doi":"10.1016/j.jcf.2021.03.011","title":"Elexacaftor co-potentiates the activity of F508del and gating mutants of CFTR","year":2021,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canada Research Chairs; National Institute of Diabetes and Digestive and Kidney Diseases; Cystic Fibrosis Canada; Canadian Institutes of Health Research; Cystic Fibrosis Foundation Therapeutics","keywords":"Medicine; Cystic fibrosis; Gating; Mutant; Pharmacology; Internal medicine; Genetics; Physiology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003894104,0.0004834284,0.001103612,0.0003521993,0.0002894008,0.0005002152,0.0005715101,0.0007884916,0.004401189],"category_scores_gemma":[0.001037234,0.0002951619,0.0006397521,0.0002683352,0.0006443157,0.0005191455,0.0004730232,0.001607909,0.0006920861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000302402,"about_ca_system_score_gemma":0.0006269738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00132746,"about_ca_topic_score_gemma":0.001850076,"domain_scores_codex":[0.9993526,0.0001481536,0.00006536249,0.00005710496,0.0001202001,0.0002564527],"domain_scores_gemma":[0.9994418,0.0002676665,0.00005388663,0.00006525707,0.00003229024,0.0001390649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007523432,0.0005855456,0.0005609191,0.0001166079,0.00006001475,0.0005950928,0.00009205636,0.0002382399,0.9846829,0.0003013643,0.0006643832,0.004579418],"study_design_scores_gemma":[0.0009454815,0.007357577,0.01526014,0.00004116081,0.0001337315,0.001344588,0.0001690897,0.00164966,0.969278,0.0001241037,0.003657694,0.00003873469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962005,0.001012811,0.0002328358,0.0003127972,0.000197892,0.00003229257,0.0002929973,0.00006996936,0.001647844],"genre_scores_gemma":[0.9961713,0.0007455981,0.0002488238,0.0001051074,0.00009199827,0.00003063498,0.0004871761,0.00002718357,0.002092113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004401189,"threshold_uncertainty_score":0.01472342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701565683145318,"score_gpt":0.3203274993903192,"score_spread":0.3033118425588661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}