{"id":"W3148352923","doi":"10.1182/blood.2020007651","title":"Targeting AXL kinase sensitizes leukemic stem and progenitor cells to venetoclax treatment in acute myeloid leukemia","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"SignalChem (Canada); Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Terry Fox Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Venetoclax; Myeloid leukemia; Progenitor cell; Cancer research; Stem cell; Leukemia; Biology; Myeloid; Immunology; Cell biology; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008792886,0.000172881,0.0002907512,0.00007088736,0.0001009837,0.00002263736,0.00005424139,0.0001529969,0.00002622495],"category_scores_gemma":[0.000009460467,0.0001594638,0.00005545983,0.0001340486,0.00003447394,0.00005920377,0.00007378835,0.00009933787,0.00009325578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003061214,"about_ca_system_score_gemma":0.0002696918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001051568,"about_ca_topic_score_gemma":0.00002528791,"domain_scores_codex":[0.9989432,0.0001465482,0.0002515985,0.0003293179,0.00002622868,0.000303119],"domain_scores_gemma":[0.999627,0.00005048872,0.00005954645,0.0001906627,0.00004209483,0.00003020023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005767673,0.0001004257,0.001599765,0.00001204689,0.0001852983,0.00007572168,0.0005220872,0.00004408887,0.9922338,0.0000171077,0.0001237729,0.005028168],"study_design_scores_gemma":[0.002742082,0.0001969291,0.006472542,0.00004357417,0.0001184649,0.0001287098,0.0002594363,0.00002039824,0.9861604,0.000008235763,0.003677271,0.0001719881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921587,0.007085718,0.00001108915,0.00006145834,0.0002429353,0.0003078435,0.00002753378,0.00003690654,0.00006787229],"genre_scores_gemma":[0.9976386,0.000302582,0.0002404631,0.00005988639,0.00004436094,0.00004596737,0.0001029459,0.00001779908,0.001547419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006783136,"threshold_uncertainty_score":0.6502744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009616529857277527,"score_gpt":0.2207454706866285,"score_spread":0.211128940829351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}