{"id":"W3148421597","doi":"10.3389/fphys.2021.645303","title":"Serum Zonulin Measured by Commercial Kit Fails to Correlate With Physiologic Measures of Altered Gut Permeability in First Degree Relatives of Crohn's Disease Patients","year":2021,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Canadian Association of Gastroenterology; Crohn's and Colitis Canada; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Intestinal permeability; Tight junction; Lactulose; Barrier function; Internal medicine; Biomarker; Albumin; Mannitol; Disease; Excretion; Medicine; Permeability (electromagnetism); Occludin; Gastroenterology; Endocrinology; Chemistry; Immunology; Biology; Biochemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003569565,0.000453579,0.0005669135,0.001061342,0.0006068806,0.0005134891,0.0003267219,0.0005370032,0.00260241],"category_scores_gemma":[0.003255869,0.0002312984,0.0002619345,0.0005635566,0.0004642672,0.0003027846,0.0003179983,0.0004909573,0.0003498494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004048605,"about_ca_system_score_gemma":0.0002454987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004584323,"about_ca_topic_score_gemma":0.00271189,"domain_scores_codex":[0.9995505,0.00008210495,0.00005004913,0.0001612275,0.00008349087,0.00007251171],"domain_scores_gemma":[0.9987275,0.0003783018,0.0004773594,0.0001017156,0.00009461063,0.0002205004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003509736,0.00003510823,0.9912114,0.00001913023,0.00003618189,0.001929132,0.000301227,0.00003241505,0.003965805,0.00003998302,0.00007537199,0.002003357],"study_design_scores_gemma":[0.00000627061,0.0001931271,0.9917424,0.000008608155,0.00004537968,0.006672917,0.0003048355,0.0001313543,0.0006408181,0.00004881356,0.0002011426,0.000004511716],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992616,0.0002426336,0.00007712854,0.0000306618,0.000006458337,0.000002009775,0.00005064609,0.000005801546,0.000323063],"genre_scores_gemma":[0.999769,0.00004982598,0.00003584196,0.00001151348,0.000004560528,0.000001317242,0.00003763423,0.0000012267,0.00008906709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004584323,"threshold_uncertainty_score":0.009115279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03778081713674758,"score_gpt":0.2435162935920729,"score_spread":0.2057354764553254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}