{"id":"W3148421597","doi":"10.3389/fphys.2021.645303","title":"Serum Zonulin Measured by Commercial Kit Fails to Correlate With Physiologic Measures of Altered Gut Permeability in First Degree Relatives of Crohn's Disease Patients","year":2021,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Canadian Association of Gastroenterology; Crohn's and Colitis Canada; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Intestinal permeability; Tight junction; Lactulose; Barrier function; Internal medicine; Biomarker; Albumin; Mannitol; Disease; Excretion; Medicine; Permeability (electromagnetism); Occludin; Gastroenterology; Endocrinology; Chemistry; Immunology; Biology; Biochemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269376,0.0002574338,0.000771384,0.0001356644,0.0001018296,0.000006936212,0.0002694421,0.0001217486,0.00002516934],"category_scores_gemma":[0.0009932889,0.0002086659,0.00009987067,0.0006249852,0.0005984008,0.0001557552,0.0001696149,0.0002880689,0.000002051108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007401761,"about_ca_system_score_gemma":0.00008777739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005030171,"about_ca_topic_score_gemma":0.000154271,"domain_scores_codex":[0.9975504,0.0006103001,0.0005123043,0.0006896342,0.0002714992,0.000365923],"domain_scores_gemma":[0.9988565,0.0001806937,0.0002386301,0.0004290716,0.0001877579,0.0001073051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007575926,0.0009174364,0.8301798,0.0001992254,0.00008875891,0.0000224945,0.004002371,0.001607962,0.1401072,0.00007061299,0.009677234,0.005551063],"study_design_scores_gemma":[0.001459143,0.0002844508,0.9888832,0.00006013806,0.00002202089,3.492933e-7,0.0003734877,0.0000909014,0.006662763,0.001645836,0.0003137873,0.0002039188],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973778,0.0002531396,0.0004314862,0.0002555552,0.000907275,0.0004077689,0.0002220988,0.00001725292,0.0001276322],"genre_scores_gemma":[0.9991475,0.00005856096,0.0003739232,0.0002691992,0.00002689086,0.00004788649,0.00001915943,0.00001522782,0.0000416308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1587034,"threshold_uncertainty_score":0.8509148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03778081713674758,"score_gpt":0.2435162935920729,"score_spread":0.2057354764553254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}