{"id":"W3148497311","doi":"10.1161/circulationaha.121.053659","title":"Dapagliflozin and Recurrent Heart Failure Hospitalizations in Heart Failure With Reduced Ejection Fraction: An Analysis of DAPA-HF","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Libin Cardiovascular Institute of Alberta","funders":"Janssen Research and Development; Relypsa; Respicardia; American Regent; National Heart, Lung, and Blood Institute; Japan Heart Foundation; Brigham and Women's Hospital; Vifor Pharma; Shionogi; Daiichi-Sankyo; Toa Eiyo; University of Glasgow; Sanofi Pasteur; University of Oxford; British Heart Foundation; Kidney Research UK; Japan Agency for Medical Research and Development; Zora Biosciences; Ironwood Pharmaceuticals, Incorporated; Medicines Company; Intarcia Therapeutics; National Institutes of Health; Regeneron Pharmaceuticals; AstraZeneca; Alnylam Pharmaceuticals; Zafgen; Esperion Therapeutics; Kowa Company; Servier; Celladon Corporation; Defense Acquisition Program Administration; Boston Scientific Corporation; GlaxoSmithKline; National Institute of Diabetes and Digestive and Kidney Diseases; Gilead Sciences; IFM Therapeutics; AstraZeneca Canada; Alere; Novo Nordisk; MyoKardia; Eisai; Cytokinetics; Sanofi; Amgen; Moderna; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Dapagliflozin; Heart failure; Ejection fraction; Hazard ratio; Internal medicine; Cardiology; Natriuretic peptide; Placebo; Proportional hazards model; Confidence interval; Diabetes mellitus; Endocrinology; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008773708,0.0009581736,0.002513025,0.0007425472,0.0003996292,0.00100992,0.001241706,0.000898217,0.002915822],"category_scores_gemma":[0.006144157,0.0006402932,0.00874354,0.0007639177,0.000465532,0.0005357154,0.001036194,0.001636895,0.0001882189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000619867,"about_ca_system_score_gemma":0.001069453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003236997,"about_ca_topic_score_gemma":0.002591328,"domain_scores_codex":[0.9960915,0.00238963,0.0002149945,0.0005272611,0.0004203988,0.0003561579],"domain_scores_gemma":[0.9938214,0.00342663,0.000914227,0.0009796771,0.0002591963,0.0005988187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.1379549,0.001388324,0.7618893,0.0007392265,0.06596351,0.0007068817,0.0002057468,0.00484478,0.001544152,0.0005515642,0.001427255,0.02278442],"study_design_scores_gemma":[0.01092412,0.009989604,0.9173169,0.00008716295,0.02851515,0.0007339871,0.0001777161,0.02930276,0.0005518338,0.000848943,0.001464025,0.00008791295],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959869,0.00222931,0.0008289487,0.0001043331,0.00003179445,0.00006831145,0.0004722577,0.00001501817,0.0002631558],"genre_scores_gemma":[0.9982898,0.0002602978,0.0004171907,0.0000716671,0.00004632796,0.00005294287,0.0005957649,0.000006539738,0.0002595153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008773708,"threshold_uncertainty_score":0.04640037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01230189645372149,"score_gpt":0.2637968652976084,"score_spread":0.2514949688438869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}