{"id":"W3148595596","doi":"10.1101/2021.03.27.436882","title":"Single Cell, Single Nucleus and Spatial RNA Sequencing of the Human Liver Identifies Hepatic Stellate Cell and Cholangiocyte Heterogeneity","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Liver physiology and pathology","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University of New Brunswick; Canada Research Chairs; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada First Research Excellence Fund; University of Toronto; Chan Zuckerberg Initiative; Public Health Agency; National Institutes of Health; Public Health Agency of Canada; PSC Partners Seeking a Cure; Silicon Valley Community Foundation","keywords":"Hepatic stellate cell; Cholangiocyte; Biology; Transcriptome; Cell; Cell type; RNA; Hepatocyte; Liver cell; Single-cell analysis; Cell biology; Computational biology; Molecular biology; Gene expression; Gene; In vitro; Genetics; Internal medicine; Medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002221872,0.0001215008,0.0001752793,0.0003247976,0.000176222,0.0002829749,0.00007671848,0.0001840952,0.0009305222],"category_scores_gemma":[0.0002199064,0.0001233105,0.0001476749,0.0002152917,0.0001913632,0.00007940239,0.0001962524,0.0001678146,0.0004581978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001101222,"about_ca_system_score_gemma":0.000179228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008790642,"about_ca_topic_score_gemma":0.002164182,"domain_scores_codex":[0.9998518,0.00002362977,0.000008603651,0.00005605055,0.00004429855,0.00001557418],"domain_scores_gemma":[0.9998776,0.00003302114,0.0000213522,0.00002025393,0.00003405882,0.0000137006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006402373,0.000004406193,0.00371122,0.00005104456,0.00001224601,0.00006289255,0.00006482941,0.0002515294,0.9909829,0.0001004103,0.0001568358,0.00453756],"study_design_scores_gemma":[0.00001570545,0.0001694205,0.1932818,0.00003883216,0.00006795189,0.001223663,0.0003971817,0.009180332,0.7829798,0.0007118129,0.01190652,0.00002689584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9592401,0.001709442,0.03208862,0.0001339854,0.00002388233,0.00003606169,0.004376326,0.0003055254,0.002086104],"genre_scores_gemma":[0.9766945,0.0007720083,0.01691223,0.0001274678,0.00001428396,0.00005614538,0.003773316,0.000105268,0.00154481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009305222,"threshold_uncertainty_score":0.003112912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0242212844417735,"score_gpt":0.2228734022015196,"score_spread":0.1986521177597461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}