{"id":"W3148689678","doi":"10.1139/bcb-2020-0604","title":"Interaction between the guanylate kinase domain of PSD-95 and the proline-rich region and microtubule binding repeats 2 and 3 of tau","year":2021,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Guanylate kinase; Cell biology; Microtubule; Scaffold protein; Biology; Binding site; Biophysics; Plasma protein binding; Chemistry; Tau protein; Biochemistry; Signal transduction; Membrane protein","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001017821,0.0002119278,0.0001319833,0.0001437234,0.0002067522,0.0002132398,0.0002186005,0.0001650552,0.0006924971],"category_scores_gemma":[0.0001777489,0.0001358168,0.0002012688,0.00009824479,0.0002108778,0.0001655241,0.0003364524,0.0002590893,0.0001878615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003337293,"about_ca_system_score_gemma":0.0002120111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001010488,"about_ca_topic_score_gemma":0.001421718,"domain_scores_codex":[0.999881,0.00002319016,0.000006228312,0.00002872799,0.00003054526,0.0000303845],"domain_scores_gemma":[0.9999406,0.00001733967,0.00001849319,0.000005455708,0.000003854682,0.00001423849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000514969,0.00001091811,0.0007014882,0.00002350529,0.000007675822,0.0001955707,0.00002240962,0.00004153113,0.997638,0.0002327595,0.00001709807,0.00105748],"study_design_scores_gemma":[0.00002083128,0.0002066323,0.04105566,0.00001500911,0.00002915585,0.001442905,0.00009126263,0.002066535,0.9514381,0.0003425302,0.003282536,0.000008868338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932913,0.002292225,0.002611459,0.00004984674,0.00001160105,0.00001283018,0.00005477894,0.00001373456,0.001662259],"genre_scores_gemma":[0.9974893,0.0003364146,0.001514712,0.00002110091,0.000003354025,0.000009129487,0.0000653484,0.000001848261,0.0005588144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001010488,"threshold_uncertainty_score":0.002421379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01822369390458349,"score_gpt":0.2881494398694026,"score_spread":0.2699257459648191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}