{"id":"W3148982371","doi":"10.1093/jnci/djh288","title":"Association Between Biallelic and Monoallelic Germline MYH Gene Mutations and Colorectal Cancer Risk","year":2004,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":260,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Cancer Institute","keywords":"MUTYH; Germline mutation; Colorectal cancer; Loss of heterozygosity; Cancer research; Germline; Mutation; Genetics; Biology; Medicine; Cancer; Gene; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002797929,0.0002344311,0.0002447064,0.0008925071,0.0005282643,0.0003813188,0.0003091378,0.0004738979,0.001546385],"category_scores_gemma":[0.001909846,0.0003461369,0.0002005463,0.0006503155,0.0004314879,0.0001476417,0.0003592863,0.0003899954,0.0001244385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006314869,"about_ca_system_score_gemma":0.0006931921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.09119587,"about_ca_topic_score_gemma":0.13555,"domain_scores_codex":[0.9996007,0.00006636308,0.00002731732,0.0001058144,0.00009561943,0.0001042864],"domain_scores_gemma":[0.9984623,0.0003121285,0.0004631355,0.0001207091,0.0001418668,0.0004998885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000667863,0.000009186843,0.9988984,0.00000211129,0.0000188489,0.00007896256,0.00003259719,0.0000126256,0.0004687136,0.00000523964,0.00001858705,0.0003878989],"study_design_scores_gemma":[0.000003887037,0.00003523687,0.9994237,0.000001333,0.00001234681,0.0003126109,0.00004715804,0.00007776959,0.00004212124,0.000005544429,0.00003675951,0.000001391642],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996451,0.00009137041,0.00002547973,0.00001215013,0.000001130272,0.000002843303,0.00004968599,0.000001560982,0.0001706236],"genre_scores_gemma":[0.9997266,0.00004290631,0.00003579839,0.000006200209,0.000001964159,0.000002116507,0.00008452981,8.382577e-7,0.00009897778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09119587,"threshold_uncertainty_score":0.1813301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03470698295483405,"score_gpt":0.3280602011779106,"score_spread":0.2933532182230766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}