{"id":"W3149114446","doi":"10.1016/j.cjca.2021.03.013","title":"Issues in Designing and Interpreting Small Clinical Trials","year":2021,"lang":"en","type":"review","venue":"Canadian Journal of Cardiology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Clinical trial; Intensive care medicine; Randomized controlled trial; Test (biology); Psychological intervention; Medical physics; Clinical study design; Research design; Alternative medicine; Internal medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.7243554,0.00284821,0.01607941,0.008457147,0.002507376,0.01663221,0.009385304,0.01086253,0.003889208],"category_scores_gemma":[0.8963005,0.004213709,0.00717195,0.009579384,0.02422432,0.0110931,0.004948404,0.02017066,0.00157175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008502262,"about_ca_system_score_gemma":0.03079109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006297235,"about_ca_topic_score_gemma":0.01368863,"domain_scores_codex":[0.1575639,0.7490087,0.05848455,0.006477382,0.02762594,0.0008395816],"domain_scores_gemma":[0.01990243,0.9472624,0.01092861,0.01103867,0.01024994,0.0006180019],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002004665,0.0001908625,0.003591602,0.1001347,0.01300638,0.0004322615,0.004582934,0.006431482,0.0005500283,0.1503012,0.05463205,0.6641418],"study_design_scores_gemma":[0.003730285,0.001233066,0.005051457,0.110336,0.0133265,0.001460976,0.001792501,0.01303383,0.001737242,0.6446628,0.2031187,0.0005167066],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002066062,0.4890629,0.3448311,0.1252737,0.02409174,0.005234119,0.000784488,0.0008773005,0.007778581],"genre_scores_gemma":[0.05758675,0.1121822,0.7544243,0.04270842,0.01653681,0.01405676,0.0002477952,0.0006356009,0.001621332],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.2756446,"threshold_uncertainty_score":0.3399189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8831990272913192,"score_gpt":0.6847381371232508,"score_spread":0.1984608901680683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}