{"id":"W3149295991","doi":"10.1016/j.toxrep.2021.03.031","title":"Massive acetaminophen overdose with metabolic acidosis refractory to N-acetylcysteine, fomepizole, and renal replacement therapy","year":2021,"lang":"en","type":"article","venue":"Toxicology Reports","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Renal replacement therapy; Medicine; Metabolic acidosis; acetaminophen overdose; Acetaminophen; Lactic acidosis; Hemodialysis; Intensive care medicine; Refractory (planetary science); Acute kidney injury; Acetylcysteine; Fulminant hepatic failure; Acidosis; Anesthesia; Internal medicine; Liver transplantation; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002519445,0.0009003904,0.0004966494,0.001084944,0.001410526,0.0009507693,0.0004768644,0.001591543,0.001052792],"category_scores_gemma":[0.001578496,0.0003513889,0.0006363103,0.0006811448,0.0009453195,0.001166373,0.0009408753,0.001651378,0.0003676172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006904362,"about_ca_system_score_gemma":0.000903805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001651221,"about_ca_topic_score_gemma":0.002310104,"domain_scores_codex":[0.999714,0.00004083938,0.00004683679,0.00005211068,0.00006818028,0.00007811587],"domain_scores_gemma":[0.9992105,0.0001586079,0.0002835266,0.00006333765,0.00006753816,0.000216551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00003102913,0.00003875132,0.01002648,0.00003710942,0.000009589568,0.9861434,0.0001697349,0.00007187109,0.001050993,0.0001989827,0.000311771,0.001910265],"study_design_scores_gemma":[0.000007625947,0.00009069566,0.005933478,0.00003765286,0.00001822267,0.9905536,0.000214875,0.0002718454,0.0009919269,0.0003370876,0.001534067,0.000008849721],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.960794,0.006698275,0.006948358,0.006986359,0.0004106259,0.0002213406,0.0001761491,0.0002151874,0.01754966],"genre_scores_gemma":[0.9937679,0.002258935,0.0009114217,0.001192443,0.0004335502,0.00001384684,0.00005203671,0.00001237699,0.001357531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001651221,"threshold_uncertainty_score":0.005009472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07470429435108071,"score_gpt":0.3791759640334719,"score_spread":0.3044716696823912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}