{"id":"W3149295991","doi":"10.1016/j.toxrep.2021.03.031","title":"Massive acetaminophen overdose with metabolic acidosis refractory to N-acetylcysteine, fomepizole, and renal replacement therapy","year":2021,"lang":"en","type":"article","venue":"Toxicology Reports","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Renal replacement therapy; Medicine; Metabolic acidosis; acetaminophen overdose; Acetaminophen; Lactic acidosis; Hemodialysis; Intensive care medicine; Refractory (planetary science); Acute kidney injury; Acetylcysteine; Fulminant hepatic failure; Acidosis; Anesthesia; Internal medicine; Liver transplantation; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001180248,0.0004821461,0.0007485501,0.000235005,0.0005173067,0.00005523056,0.0001544763,0.0007392083,0.001568401],"category_scores_gemma":[0.0002188279,0.0004370606,0.0001208085,0.0005869659,0.0002469567,0.0002500072,0.0002221429,0.001114081,0.00005044433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001683891,"about_ca_system_score_gemma":0.0003910438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005055788,"about_ca_topic_score_gemma":0.000148695,"domain_scores_codex":[0.9961287,0.0009403781,0.0007397412,0.00108696,0.0003207873,0.0007834313],"domain_scores_gemma":[0.997723,0.0002651571,0.000484901,0.0006832003,0.0002887673,0.0005549336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002660979,0.001034758,0.02496929,0.00006533282,0.001143349,0.00413799,0.001893061,0.0004634752,0.8998697,0.0006068322,0.002892394,0.06026279],"study_design_scores_gemma":[0.002353858,0.001018354,0.01351,0.00002646229,0.0001870718,0.002129522,0.0001958425,0.00004742524,0.5002177,0.0002470664,0.4795684,0.0004982668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854046,0.002476809,0.0002863943,0.002699338,0.001380027,0.001316777,0.00003141709,0.0002001083,0.0062046],"genre_scores_gemma":[0.9839706,0.001223539,0.001129081,0.007214731,0.0003693724,0.000598621,0.00004541143,0.00006419501,0.005384473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.476676,"threshold_uncertainty_score":0.9998081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07470429435108071,"score_gpt":0.3791759640334719,"score_spread":0.3044716696823912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}