{"id":"W3149297331","doi":"10.3390/pharmaceutics13040479","title":"Viscous Core Liposomes Increase siRNA Encapsulation and Provides Gene Inhibition When Slightly Positively Charged","year":2021,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Université de Paris; Higher Education Commision, Pakistan; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale","keywords":"Liposome; Transfection; Cationic liposome; Chemistry; Gene delivery; Biophysics; Membrane; Drug delivery; Small interfering RNA; Encapsulation (networking); Nanotechnology; Materials science; Biochemistry; Gene; Computer science; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009868584,0.0001545561,0.0001210993,0.0000369028,0.00009984434,0.00005310682,0.00005970816,0.0001036751,0.00004629468],"category_scores_gemma":[0.0000546319,0.0001579128,0.00005251469,0.00005761809,0.00005328875,0.00001476447,0.0001115169,0.00009555338,0.00001689338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001584284,"about_ca_system_score_gemma":0.00008866767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001534719,"about_ca_topic_score_gemma":0.00001285113,"domain_scores_codex":[0.9991166,0.00005954981,0.0001828194,0.0003267344,0.0001200666,0.0001942582],"domain_scores_gemma":[0.9994385,0.00001235667,0.00007441882,0.0001586619,0.0002058218,0.000110261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001003318,0.00006908328,0.003126164,0.00003065423,0.00006467094,0.00003279197,0.0001534586,0.00001104959,0.9916208,0.0000387704,0.000677866,0.004074339],"study_design_scores_gemma":[0.000619892,0.0001182459,0.003916364,0.00002478916,0.00006551536,0.00009727495,0.00006599251,0.0007064138,0.988216,0.0001869214,0.005780217,0.0002023551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950403,0.00335244,0.0004622783,0.0003553977,0.0001295969,0.0001541273,0.00006925192,0.00001767549,0.0004189388],"genre_scores_gemma":[0.9946463,0.002055674,0.0006889625,0.001212909,0.0002960424,0.00001508256,0.0005093882,0.00001891901,0.0005567161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005102351,"threshold_uncertainty_score":0.6439497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03381890983631181,"score_gpt":0.3002225852722029,"score_spread":0.2664036754358911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}