{"id":"W3149297331","doi":"10.3390/pharmaceutics13040479","title":"Viscous Core Liposomes Increase siRNA Encapsulation and Provides Gene Inhibition When Slightly Positively Charged","year":2021,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Université de Paris; Higher Education Commision, Pakistan; Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale","keywords":"Liposome; Transfection; Cationic liposome; Chemistry; Gene delivery; Biophysics; Membrane; Drug delivery; Small interfering RNA; Encapsulation (networking); Nanotechnology; Materials science; Biochemistry; Gene; Computer science; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000191798,0.0004735506,0.0002384196,0.0003324052,0.00008542931,0.0003679161,0.0001706969,0.000320723,0.001576044],"category_scores_gemma":[0.0002690825,0.0001700993,0.0002405009,0.0001223033,0.000178145,0.0003461538,0.0003137899,0.0003126957,0.0004124414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002780649,"about_ca_system_score_gemma":0.0001581335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003001759,"about_ca_topic_score_gemma":0.0003695831,"domain_scores_codex":[0.9998604,0.00002616148,0.00001437871,0.00003529085,0.0000379942,0.00002568128],"domain_scores_gemma":[0.9998109,0.00005107989,0.00006445457,0.00001238185,0.00003562063,0.00002559548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003888455,0.00001126078,0.00004971261,0.00003326685,0.000003560895,0.00002577992,0.00001102434,0.00004701917,0.9980273,0.0001135215,0.00002801243,0.001610653],"study_design_scores_gemma":[0.000005511381,0.00007253558,0.0003176289,0.000003478233,0.00001065446,0.00005723101,0.000004139558,0.0003241486,0.997983,0.00002401412,0.00119493,0.00000271959],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9530662,0.004516173,0.0352845,0.0002614901,0.0000770694,0.0001532034,0.0003728788,0.000543093,0.005725359],"genre_scores_gemma":[0.9850489,0.001220367,0.009256925,0.00009949641,0.00001361783,0.00006235691,0.0002357045,0.00006864627,0.003993905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001576044,"threshold_uncertainty_score":0.005272388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03381890983631181,"score_gpt":0.3002225852722029,"score_spread":0.2664036754358911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}