{"id":"W3149804071","doi":"10.18632/aging.202913","title":"Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial","year":2021,"lang":"en","type":"article","venue":"Aging","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":357,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Randomized controlled trial; Medicine; Clinical trial; Epigenetics; Population; Statistical significance; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002446726,0.001420643,0.002305067,0.0004113772,0.000596258,0.0007795127,0.0006815458,0.002214975,0.00667807],"category_scores_gemma":[0.002470969,0.0004807395,0.001840938,0.0004379763,0.001015407,0.0007945453,0.0004797406,0.001855857,0.0007777272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004653987,"about_ca_system_score_gemma":0.001271504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007142145,"about_ca_topic_score_gemma":0.001340912,"domain_scores_codex":[0.9990358,0.000526615,0.00007961953,0.0001782651,0.00006497285,0.0001145631],"domain_scores_gemma":[0.9987254,0.0004045886,0.0002738325,0.0001271955,0.0001187901,0.0003501767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9543696,0.02119129,0.0006932972,0.001001212,0.001482926,0.00005818197,0.00005127548,0.0001483265,0.002452339,0.0001324948,0.0006707602,0.01774839],"study_design_scores_gemma":[0.8700079,0.1261037,0.001762577,0.00006091267,0.0007408544,0.00002360223,0.00002417639,0.000209548,0.0003197838,0.0001705893,0.0005658506,0.00001055948],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623389,0.007983742,0.001997679,0.001550582,0.001349425,0.02094901,0.001111392,0.0001914228,0.002527898],"genre_scores_gemma":[0.9566475,0.003964419,0.005868536,0.001985049,0.0007998287,0.02657942,0.0007170505,0.00002420073,0.003414088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00667807,"threshold_uncertainty_score":0.02234036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03830636806591745,"score_gpt":0.3525683630506546,"score_spread":0.3142619949847372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}