{"id":"W3149804071","doi":"10.18632/aging.202913","title":"Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial","year":2021,"lang":"en","type":"article","venue":"Aging","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":357,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Randomized controlled trial; Medicine; Clinical trial; Epigenetics; Population; Statistical significance; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00119298,0.00009180345,0.0002962546,0.00002622846,0.00004558055,0.00002472588,0.00005619196,0.00007838458,0.00001528564],"category_scores_gemma":[0.0005564979,0.00009127578,0.0002145008,0.00005456331,0.0001141949,0.000002869166,0.0001345288,0.00006937206,5.585331e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000385838,"about_ca_system_score_gemma":0.00005103516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003612868,"about_ca_topic_score_gemma":0.00001585327,"domain_scores_codex":[0.9984789,0.0005484244,0.0004882511,0.000266535,0.00009608983,0.0001217718],"domain_scores_gemma":[0.9994295,0.0000711147,0.0001693303,0.0001933666,0.0000811985,0.00005548737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.155398,0.0004797814,0.003530791,0.0001102218,0.0003972505,0.00006637721,0.0001161717,0.0002321596,0.8300689,0.00009707611,0.00003132519,0.009471862],"study_design_scores_gemma":[0.7006062,0.002388095,0.00298247,0.0001800136,0.0004979369,0.00001990862,0.0001428718,0.00294041,0.2871257,0.001311374,0.00135727,0.0004477897],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617674,0.003888147,0.0335569,0.00004856057,0.0004101029,0.0002022392,0.000003463337,0.000004103062,0.0001190529],"genre_scores_gemma":[0.9944497,0.0008300474,0.004058679,0.00003482218,0.0004126014,0.000006077729,0.00004349818,0.00001289111,0.0001516425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5452082,"threshold_uncertainty_score":0.3722118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03830636806591745,"score_gpt":0.3525683630506546,"score_spread":0.3142619949847372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}