{"id":"W3150017696","doi":"10.1016/j.mce.2021.111269","title":"Nesfatin-1 and Nesfatin-1-like peptide suppress basal and TRH-Induced expression of prolactin and prolactin regulatory element-binding protein mRNAs in rat GH3 somatolactotrophs","year":2021,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Western College of Veterinary Medicine, University of Saskatchewan; Saskatchewan Health Research Foundation; University of Saskatchewan","keywords":"Prolactin; Gene knockdown; Thyrotropin-releasing hormone; Internal medicine; Endogeny; Endocrinology; Biology; Anterior pituitary; Gene silencing; Prolactin cell; Hormone; Hypothalamus; Cell culture; Gene; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002297112,0.0005927399,0.0003727068,0.0005386064,0.0003047978,0.0003476914,0.0003150726,0.000298872,0.00173144],"category_scores_gemma":[0.0003366603,0.0003758391,0.0004191351,0.0002479347,0.0007105999,0.0003586793,0.0002737807,0.0009623446,0.0004078872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004721217,"about_ca_system_score_gemma":0.0004465775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293478,"about_ca_topic_score_gemma":0.002274333,"domain_scores_codex":[0.9997922,0.00003371604,0.00001651197,0.00002921639,0.00003847449,0.00008989229],"domain_scores_gemma":[0.9995404,0.0001654005,0.00006012563,0.00003897364,0.00003167323,0.0001633269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001339067,0.00005528162,0.0001399158,0.00001833194,0.000003968985,0.00006716257,0.00002608484,0.00004274816,0.9976302,0.00006029135,0.00002663559,0.0005902685],"study_design_scores_gemma":[0.00009556782,0.0009552809,0.005504712,0.000004359014,0.00001888339,0.0002211085,0.00008305396,0.0007333836,0.991222,0.00009568829,0.001056263,0.000009609775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973121,0.000705119,0.0008590134,0.0001015774,0.00004103993,0.00001588625,0.0002395774,0.00005484188,0.0006710207],"genre_scores_gemma":[0.9906893,0.0006060892,0.002133813,0.0001245756,0.00005804232,0.00006680414,0.001361205,0.00006881543,0.004891494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00173144,"threshold_uncertainty_score":0.005792201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104787969882564,"score_gpt":0.2288299183596367,"score_spread":0.2183511213713803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}