{"id":"W3150310237","doi":"10.1002/etc.5054","title":"Chronic Embryo-Larval Exposure of Fathead Minnows to the Pharmaceutical Drug Metformin: Survival, Growth, and Microbiome Responses","year":2021,"lang":"en","type":"article","venue":"Environmental Toxicology and Chemistry","topic":"Pharmaceutical and Antibiotic Environmental Impacts","field":"Environmental Science","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Environment and Climate Change Canada","funders":"Health Canada","keywords":"Metformin; Microbiome; Biology; Firmicutes; Bacteroidetes; Larva; Proteobacteria; Pimephales promelas; Animal science; Minnow; Toxicology; Endocrinology; Ecology; Bacteria; Diabetes mellitus; 16S ribosomal RNA; Fish <Actinopterygii>; Bioinformatics; Fishery; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009789335,0.0002612018,0.0002731771,0.0001041184,0.000179835,0.0002268724,0.0001441188,0.0003465473,0.001075451],"category_scores_gemma":[0.0001514976,0.0001547468,0.0002566362,0.00006731103,0.000150545,0.0002519894,0.000287272,0.0004571453,0.000168001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003894145,"about_ca_system_score_gemma":0.0002551993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001853664,"about_ca_topic_score_gemma":0.005814839,"domain_scores_codex":[0.999885,0.0000108315,0.000009299224,0.00004510592,0.0000226606,0.00002718719],"domain_scores_gemma":[0.9999095,0.000009399637,0.00003123477,0.000006471578,0.00001906052,0.00002435363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001075565,0.0001092625,0.01056142,0.0000590808,0.00001600531,0.00006213281,0.00008210345,0.00006467547,0.9842535,0.00001874443,0.00007615504,0.003621277],"study_design_scores_gemma":[0.00004057359,0.0072778,0.4490266,0.00003248898,0.0001048272,0.0002392297,0.0006483614,0.000791258,0.5394191,0.00006562127,0.0023251,0.00002904391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990835,0.0002352011,0.0001198931,0.00003858059,0.00001001768,0.000008557008,0.0002668968,0.000003918249,0.0002333334],"genre_scores_gemma":[0.9958317,0.0003392501,0.0005364789,0.0001419236,0.000007543037,0.00004939926,0.0005999592,0.000004717027,0.002489061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001853664,"threshold_uncertainty_score":0.003685713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0150805260344377,"score_gpt":0.268120819299762,"score_spread":0.2530402932653243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}