{"id":"W3150529150","doi":"10.1161/atvbaha.121.315933","title":"HSP25 Vaccination Attenuates Atherogenesis via Upregulation of LDLR Expression, Lowering of PCSK9 Levels and Curbing of Inflammation","year":2021,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Libin Cardiovascular Institute of Alberta","funders":"National Institute on Minority Health and Health Disparities","keywords":"PCSK9; LDL receptor; Inflammation; Kexin; Endocrinology; Internal medicine; Apolipoprotein B; Immune system; Biology; Antibody; Proprotein convertase; Cholesterol; Lipoprotein; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009304411,0.0004227456,0.0002534718,0.0002391586,0.0001098748,0.0001532369,0.0001161424,0.0001664762,0.001823027],"category_scores_gemma":[0.00007412987,0.0001003996,0.0002701073,0.00008866236,0.0002278138,0.0001425365,0.0001383961,0.0004674158,0.0003203743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001443547,"about_ca_system_score_gemma":0.0001546838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002814627,"about_ca_topic_score_gemma":0.0004810546,"domain_scores_codex":[0.9999183,0.00001165627,0.000007543126,0.00001483776,0.00001878794,0.00002877894],"domain_scores_gemma":[0.9999286,0.000004283334,0.00002335765,0.000007121751,0.000006801536,0.00002979729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009001627,0.0002842394,0.0002434602,0.00007280447,0.00001484494,0.0000527198,0.000008741634,0.00008898253,0.9941993,0.00004721268,0.0001240424,0.003963469],"study_design_scores_gemma":[0.0001915803,0.007378398,0.01628082,0.00002342593,0.00009216895,0.000474008,0.00004362256,0.00086934,0.9714506,0.00007209086,0.003114615,0.000009351005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970582,0.0007990629,0.001003393,0.00008016683,0.00003899619,0.00003424636,0.0001374252,0.0001321834,0.0007164099],"genre_scores_gemma":[0.9950019,0.0008293385,0.0008741201,0.00006882611,0.0000338562,0.00003799113,0.0003356421,0.0000193947,0.002798985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001823027,"threshold_uncertainty_score":0.006098688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03261296450551272,"score_gpt":0.2989035538160178,"score_spread":0.2662905893105051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}