{"id":"W3150878436","doi":"10.1093/noajnl/vdab024.004","title":"BIMG-05. TO BE OR NOT TO BE GLYCOLYTIC: DEUTERATED GLUCOSE-BASED ASSESSMENT OF THE WARBURG EFFECT ALLOWS NON-INVASIVE IMAGING OF TUMOR BURDEN AND TREATMENT RESPONSE IN MUTANT IDH GLIOMAS <i>IN VIVO</i>","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Warburg effect; Glioma; Glycolysis; Isocitrate dehydrogenase; Cancer research; Lactate dehydrogenase A; Glucose uptake; Biology; Brain tumor; Chemistry; Pathology; Biochemistry; Medicine; Metabolism; Endocrinology; Insulin; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003714491,0.000272683,0.0005932114,0.0001519315,0.00005196965,0.00001247124,0.0002073996,0.00009159497,0.00001344299],"category_scores_gemma":[0.0007215882,0.0002010051,0.0001157255,0.0004694364,0.0001401501,0.00001120463,0.0001708139,0.0001119379,2.625927e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113563,"about_ca_system_score_gemma":0.00117753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009784722,"about_ca_topic_score_gemma":0.002291425,"domain_scores_codex":[0.9977893,0.0006145482,0.000451897,0.000611479,0.0001781924,0.0003546441],"domain_scores_gemma":[0.9985214,0.0006065715,0.0001723842,0.0004412855,0.0001211964,0.0001371335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007686958,0.0001702955,0.002252895,0.00004762358,0.00003290076,0.0002549428,0.000293315,0.001977758,0.9827952,0.000003392898,0.00007650971,0.004408247],"study_design_scores_gemma":[0.003810057,0.002737169,0.00500845,0.00005985459,0.00005396521,0.0000696819,0.0002258407,0.0001387983,0.8938615,0.000002562135,0.09385829,0.0001738719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940689,0.0009724045,0.00006053842,0.003059243,0.0006895666,0.0009575546,0.0001264036,0.000006512073,0.0000589298],"genre_scores_gemma":[0.9938002,0.000618689,0.0009670409,0.004123532,0.000151992,0.0002434928,0.00001064083,0.00002682769,0.00005760124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09378178,"threshold_uncertainty_score":0.8196748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089093669286835,"score_gpt":0.3046862228530359,"score_spread":0.2937952861601675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}