{"id":"W3150878436","doi":"10.1093/noajnl/vdab024.004","title":"BIMG-05. TO BE OR NOT TO BE GLYCOLYTIC: DEUTERATED GLUCOSE-BASED ASSESSMENT OF THE WARBURG EFFECT ALLOWS NON-INVASIVE IMAGING OF TUMOR BURDEN AND TREATMENT RESPONSE IN MUTANT IDH GLIOMAS <i>IN VIVO</i>","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Warburg effect; Glioma; Glycolysis; Isocitrate dehydrogenase; Cancer research; Lactate dehydrogenase A; Glucose uptake; Biology; Brain tumor; Chemistry; Pathology; Biochemistry; Medicine; Metabolism; Endocrinology; Insulin; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003547751,0.0004719191,0.0005562615,0.0002981659,0.0003116751,0.0003858746,0.000375653,0.0005794982,0.004425249],"category_scores_gemma":[0.0001798616,0.0001915527,0.0002837397,0.0003140997,0.0003917944,0.0002877852,0.0002254241,0.001154238,0.0008888351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005527162,"about_ca_system_score_gemma":0.0006887423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001924298,"about_ca_topic_score_gemma":0.001958462,"domain_scores_codex":[0.9996563,0.00005999112,0.00002366175,0.00007034291,0.00008417307,0.0001055068],"domain_scores_gemma":[0.9998372,0.00001593124,0.00003184906,0.00001398033,0.00001585781,0.00008521082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00255229,0.001027739,0.000472255,0.00007063748,0.00002732754,0.00009919655,0.00002954907,0.0002844587,0.987214,0.0006533285,0.001481533,0.006087787],"study_design_scores_gemma":[0.0003449743,0.006296692,0.004967888,0.00001932592,0.00005062215,0.0003670569,0.00005799122,0.002841529,0.9745364,0.0002430431,0.0102534,0.00002120657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986779,0.0008653756,0.002311553,0.000580503,0.0002745104,0.0001609931,0.002858508,0.0002835286,0.005886016],"genre_scores_gemma":[0.9754921,0.0006686588,0.00512149,0.000618981,0.00003520137,0.0004852096,0.00487819,0.0001365069,0.01256366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004425249,"threshold_uncertainty_score":0.01480395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089093669286835,"score_gpt":0.3046862228530359,"score_spread":0.2937952861601675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}