{"id":"W3150928009","doi":"10.3389/fcell.2021.661298","title":"Autophagy Inhibitors Do Not Restore Peroxisomal Functions in Cells With the Most Common Peroxisome Biogenesis Defect","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"FP7 People: Marie-Curie Actions; ZonMw; E-Rare; Hersenstichting; McGill University Health Centre; McGill University","keywords":"Peroxisome; Autophagy; Biogenesis; Cell biology; Peroxisome proliferator; Biology; Chemistry; Biochemistry; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001889727,0.0002976714,0.0003116755,0.0001576331,0.0001789649,0.00003451375,0.0001845114,0.0003510934,0.00003023213],"category_scores_gemma":[0.00002230369,0.0002224144,0.00006455496,0.0004334981,0.0003140542,0.00001136899,0.0002318228,0.0002597426,0.000008767922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001070195,"about_ca_system_score_gemma":0.0002696818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006279048,"about_ca_topic_score_gemma":0.0003612642,"domain_scores_codex":[0.9982594,0.0002322354,0.0003040581,0.0006578968,0.00009982218,0.0004466303],"domain_scores_gemma":[0.9995239,0.00003222118,0.00007753576,0.0002227969,0.00004346147,0.0001000609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002073461,0.0001057679,0.2924317,0.00001460697,0.0000517986,0.00002198542,0.0002055829,0.0000213122,0.7007729,0.00000480229,0.004334491,0.001827759],"study_design_scores_gemma":[0.00113677,0.0002360848,0.01060266,0.00001776828,0.00001323136,0.00005502847,0.002482546,0.00001117145,0.9600696,0.00001614671,0.02499736,0.0003616246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99435,0.003574168,0.0001442803,0.0002075114,0.0006210191,0.0002269923,0.00005332449,0.00001506419,0.0008076694],"genre_scores_gemma":[0.9953286,0.0005439579,0.002654343,0.0004539032,0.00008333826,0.00007810552,0.0002724001,0.00003090456,0.0005544394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.281829,"threshold_uncertainty_score":0.9069798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005522642528141421,"score_gpt":0.1994100000586987,"score_spread":0.1938873575305573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}