{"id":"W3150954888","doi":"10.3389/fcell.2021.664696","title":"Endothelial Cell Behavior Is Determined by Receptor Clustering Induced by Thrombospondin-1","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cell and Developmental Biology","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Canadian Institutes of Health Research; Cancer Research Society; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Ovarian Cancer Canada","keywords":"Cell biology; Thrombospondins; Angiogenesis; CD47; Tetraspanin; Thrombospondin 1; Biology; LRP1; Thrombospondin; Lipid raft; Integrin; Signal transduction; Cell surface receptor; Receptor; Extracellular matrix; LDL receptor; Cell; Cancer research; Biochemistry; Lipoprotein; Matrix metalloproteinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002465998,0.0004870695,0.0007872964,0.001003049,0.00016201,0.0006583579,0.0004460963,0.0006083095,0.001380706],"category_scores_gemma":[0.0002364781,0.0002395073,0.0002229567,0.0010145,0.0003196308,0.0006624837,0.0004231943,0.00113292,0.001538742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005854607,"about_ca_system_score_gemma":0.0005108818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007595041,"about_ca_topic_score_gemma":0.0009686766,"domain_scores_codex":[0.9999175,0.00001337658,0.00001097697,0.00001958304,0.00002777364,0.00001073182],"domain_scores_gemma":[0.9999219,0.00002566738,0.00001241973,0.000002426937,0.00002857132,0.000009008259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000128188,0.00004886405,0.000265988,0.01290339,0.00007625431,0.0003503625,0.00007476694,0.0005848752,0.01317351,0.007591981,0.02379867,0.9410031],"study_design_scores_gemma":[0.00002616035,0.0001298303,0.001835345,0.001830607,0.0001017276,0.001949143,0.00005255607,0.0002181913,0.004747794,0.002698636,0.9863799,0.0000300357],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003850326,0.9975783,0.0002126156,0.0002518493,0.0001530671,0.000004118612,0.00002534091,0.000008174887,0.001381422],"genre_scores_gemma":[0.001566886,0.9972161,0.0001361653,0.0001354847,0.00009207694,0.000006725807,0.00003232741,0.000001464323,0.0008127188],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001380706,"threshold_uncertainty_score":0.004618943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010330227507265,"score_gpt":0.2796675202146163,"score_spread":0.2595642179395436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}