{"id":"W3151024940","doi":"10.1101/2021.04.08.438361","title":"CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Telesta Therapeutics (Canada); Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cyclin E1; Cyclin-dependent kinase 1; FOXM1; Synthetic lethality; Cancer research; Mitosis; Biology; Cyclin; Cell cycle; Gene; Cell biology; DNA repair; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002441874,0.0004960409,0.0003429574,0.0001137662,0.0001071138,0.0001864053,0.0002562973,0.0005821451,0.00004426142],"category_scores_gemma":[0.00008485944,0.0005349093,0.0001485891,0.000218355,0.00009409184,0.000008205096,0.0003237614,0.0004124085,0.00001840628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007079163,"about_ca_system_score_gemma":0.0003466366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002384158,"about_ca_topic_score_gemma":0.000004252325,"domain_scores_codex":[0.997725,0.00006967815,0.000356984,0.001131955,0.000290307,0.0004260986],"domain_scores_gemma":[0.9977278,0.00001108027,0.0001990953,0.001420938,0.0004334455,0.0002076407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003261364,0.00009852624,0.0007412573,0.0002336817,0.0001196674,0.00003955565,0.00001190568,0.0003992529,0.9980003,0.00003960087,0.0002777324,0.000005933916],"study_design_scores_gemma":[0.000376809,0.00008966324,0.01087039,0.0003008107,0.0001035185,1.765835e-7,0.0000102201,0.0001623253,0.9823564,4.720678e-7,0.005040597,0.0006886332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9503912,0.002093457,0.04621198,0.0001952907,0.0004261363,0.0004190898,0.0001388443,0.0001021212,0.00002190675],"genre_scores_gemma":[0.9916068,0.0003915264,0.006968454,0.0001965706,0.0005044333,0.0001778757,0.000008526472,0.0001340425,0.00001178201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04121561,"threshold_uncertainty_score":0.9997103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008112031588759085,"score_gpt":0.234323116314128,"score_spread":0.2262110847253689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}